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Linking Splicing to Pol II Transcription Stabilizes Pre-mRNAs and Influences Splicing Patterns

Figure 4

Minimal Kinetic Scheme of the In Vitro Reaction Linking Pol II Transcription with Pre-mRNA Splicing

The diagram shows a series of dissociation and association constants for the formation of complexes between the DNA template and the transcription machinery, between the pre-mRNA and ribonucleases or the splicing machinery, and between the spliced mRNA and ribonucleases. The catalytic rate constants describe the conversion of NTPs to pre-mRNA for transcription, the conversion of pre-mRNA to mRNA for splicing, and the conversion of pre-mRNA or mRNA to nucleotide monophosphate for ribonuclease digestion.

Figure 4