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The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

Figure 1

Joint Refinement of C. elegans and C. briggsae Gene Models: acy-4

When annotating the C. briggsae and C. elegans acy-4 orthologs, we chose the Genefinder ce-acy-4 prediction and the Genefinder cb-acy-4 prediction because, out of the 12 possible combinations of a C. briggsae and a C. elegans prediction, this pair shows the most similarity to each other. Coding sequence (CDS) conservation between cb-acy-4 and ce-acy-4 provides evidence for as many as 12 additional N-terminal exons in the Genefinder ce-acy-4 prediction, as compared to T01C2.1, the WS77 ce-acy-4 prediction. Subsequently, four of the additional N-terminal exons that were predicted by FGENESH and Genefinder were confirmed by new EST data (marked with asterisks).

Figure 1

doi: https://doi.org/10.1371/journal.pbio.0000045.g001