The locus coeruleus influences behavior by coordinating effective integration of fear memories and sensory input
Fig 9
Summary on the neural circuit mediating the transition from memory retrieval to freezing behavior.
Presentation of CS+ activates LA neurons and TeA neurons. The activated LA neurons activate dmPFC T-neurons, which in turn activate dmPFC S-neurons and LC neurons. S-neurons receive inputs from TeA and send their outputs to BLA, which projects to PAG to enable freezing behavior. Activated LC neurons release NE in the dmPFC via their projections.