Two distinct subpopulations of human stem-like memory T cells exhibit complementary roles in self-renewal and clonal longevity
Fig 9
Predictions of winning model – Model D (linear, CD95int first) overlaid (NOT fitted) onto a novel data set.
(A) The winning model and best fit parameters were used to predict the long-term dynamics of YFV-specific CD95int TSCM (left) and CD95hi TSCM (right) for each individual (shown by colored lines: DW19 in blue, DW20 in pink, DW25 in orange). For CD95int the predictions overlay and only one line can be seen. The predictions are plotted against but not fitted to a proxy for CD95int and CD95hi TSCM frequencies measured in the cross-sectional cohort post-vaccination (the same cohort for which total TSCM were fitted). (B) As above but also including 100 predictions obtained by fitting bootstrapped data (sampled with replacement) shown as grey lines. A comparison of all models to this unseen data set is provided in Table L in S2 Text. The data underlying this figure can be found in S1 Data.