Environmental noise-induced changes to the IC-SNc circuit promotes motor deficits and neuronal vulnerability in a mouse model of Parkinson’s Disease

• Chi Cui ,

  Contributed equally to this work with: Chi Cui, Yibo Yao

  Roles Data curation, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Hubei Provincial Clinical Research Center for Alzheimer’s Disease, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Yibo Yao ,

  Contributed equally to this work with: Chi Cui, Yibo Yao

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Yulong Shi,

  Roles Validation, Writing – review & editing

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Jie Lei,

  Roles Data curation, Formal analysis

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Kun Ren,

  Roles Validation, Visualization

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Kexing Wan,

  Roles Validation, Visualization

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Tongxia Li,

  Roles Methodology

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Gangan Luo,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Qian Xu,

  Roles Writing – review & editing

  Affiliation School of Clinical Traditional Chinese Medicine, Hubei University of Chinese Medicine, Wuhan, Hubei, China

  ⨯
• Ming Li,

  Roles Validation

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Xiang Peng,

  Roles Data curation

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Xueke Yang,

  Roles Formal analysis

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Jian Yang,

  Roles Writing – review & editing

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Junsong Du,

  Roles Validation

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

  ⨯
• Sitong Chen,

  Roles Visualization

  Affiliation Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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• Bo Tian ,

  Roles Funding acquisition, Investigation, Project administration, Resources, Software, Supervision, Writing – review & editing

  * E-mail: tianbo@wust.edu.cn (BT); zhangpei@hust.edu.cn (PZ)

  Affiliation Hubei Provincial Clinical Research Center for Alzheimer’s Disease, Tianyou Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China

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•  [ ... ],
• Pei Zhang

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – review & editing

  * E-mail: tianbo@wust.edu.cn (BT); zhangpei@hust.edu.cn (PZ)

  Affiliations Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Institute for Brain Research, Huazhong University of Science and Technology, Wuhan, Hubei, China, Key Laboratory of Neurological Diseases, Ministry of Education, Wuhan, Hubei, China

  https://orcid.org/0000-0003-0608-5677

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