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Open Access
Peer-reviewed
Research Article
Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
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Linxiang Yin,
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft
Affiliation Department of Urology, Boston Children’s Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
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Geoffrey Masuyer ,
Contributed equally to this work with: Geoffrey Masuyer, Sicai Zhang
Roles Data curation, Formal analysis, Investigation
Current address: Department of Pharmacy and Pharmacology, University of Bath, United Kingdom
Affiliation Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
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Sicai Zhang ,
Contributed equally to this work with: Geoffrey Masuyer, Sicai Zhang
Roles Conceptualization, Data curation, Formal analysis, Investigation
Affiliation Department of Urology, Boston Children’s Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
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Jie Zhang,
Roles Investigation
Affiliation Department of Urology, Boston Children’s Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
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Shin-Ichiro Miyashita,
Roles Investigation, Resources
Affiliation Department of Urology, Boston Children’s Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
⨯ - David Burgin,
- Laura Lovelock,
- Shu-Fen Coker,
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Tian-min Fu,
Roles Investigation, Resources
Affiliation Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Boston, Massachusetts, United States of America
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Pål Stenmark ,
Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft
* E-mail: stenmark@dbb.su.se (PS); min.dong@childrens.harvard.edu (MD)
Affiliations Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden, Department of Experimental Medical Science, Lund University, Lund, Sweden
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Min Dong
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: stenmark@dbb.su.se (PS); min.dong@childrens.harvard.edu (MD)
Affiliation Department of Urology, Boston Children’s Hospital, Department of Microbiology and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America
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Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy
- Linxiang Yin,
- Geoffrey Masuyer,
- Sicai Zhang,
- Jie Zhang,
- Shin-Ichiro Miyashita,
- David Burgin,
- Laura Lovelock,
- Shu-Fen Coker,
- Tian-min Fu,
- Pål Stenmark
- Published: March 17, 2020
- https://doi.org/10.1371/journal.pbio.3000618