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Open Access
Peer-reviewed
Research Article
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output
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Chad J. Miller,
Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Hua Jane Lou,
Roles Data curation, Investigation, Resources
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Craig Simpson,
Roles Methodology, Resources
Affiliation Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Bert van de Kooij,
Roles Methodology, Resources, Writing – review & editing
Affiliation Departments of Biological Engineering and Biology, MIT Center for Precision Cancer Medicine and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Byung Hak Ha,
Roles Investigation, Resources
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Oriana S. Fisher,
Roles Resources, Writing – review & editing
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Natasha L. Pirman,
Roles Methodology, Resources
Affiliation Department of Cellular and Molecular Physiology and Systems Biology Institute, Yale University, New Haven, Connecticut, United States of America
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Titus J. Boggon,
Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Jesse Rinehart,
Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliation Department of Cellular and Molecular Physiology and Systems Biology Institute, Yale University, New Haven, Connecticut, United States of America
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Michael B. Yaffe,
Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliation Departments of Biological Engineering and Biology, MIT Center for Precision Cancer Medicine and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
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Rune Linding,
Roles Conceptualization, Funding acquisition, Methodology, Resources, Writing – review & editing
Affiliation Biotech Research and Innovation Center, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Benjamin E. Turk
Roles Conceptualization, Data curation, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: ben.turk@yale.edu
Affiliation Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, United States of America
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Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output
- Chad J. Miller,
- Hua Jane Lou,
- Craig Simpson,
- Bert van de Kooij,
- Byung Hak Ha,
- Oriana S. Fisher,
- Natasha L. Pirman,
- Titus J. Boggon,
- Jesse Rinehart,
- Michael B. Yaffe
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- Published: March 21, 2019
- https://doi.org/10.1371/journal.pbio.2006540