CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

• Niloofar Ale-Agha ,

  Contributed equally to this work with: Niloofar Ale-Agha, Christine Goy, Philipp Jakobs

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Christine Goy ,

  Contributed equally to this work with: Niloofar Ale-Agha, Christine Goy, Philipp Jakobs

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Philipp Jakobs ,

  Contributed equally to this work with: Niloofar Ale-Agha, Christine Goy, Philipp Jakobs

  Roles Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Ioakim Spyridopoulos,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom

  ⨯
• Stefanie Gonnissen,

  Roles Investigation, Methodology

  Affiliation Core Unit Biosafety Level 2 Laboratory, IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Nadine Dyballa-Rukes,

  Roles Formal analysis, Methodology, Validation

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Karin Aufenvenne,

  Roles Investigation, Methodology

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Florian von Ameln,

  Roles Investigation, Methodology, Validation

  Affiliations Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany, Core Unit Biosafety Level 2 Laboratory, IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Mark Zurek,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Tim Spannbrucker,

  Roles Investigation, Methodology, Visualization

  Affiliation Environmentally-induced Skin and Lung Aging, IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Olaf Eckermann,

  Roles Investigation, Methodology, Visualization

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Sascha Jakob,

  Roles Methodology, Validation

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Simone Gorressen,

  Roles Investigation, Methodology

  Affiliation Institute for Pharmacology and Clinical Pharmacology, Medical Faculty, HHU Duesseldorf, Duesseldorf, Germany

  ⨯
• Marcel Abrams,

  Roles Investigation, Methodology

  Affiliation Institute for Pharmacology and Clinical Pharmacology, Medical Faculty, HHU Duesseldorf, Duesseldorf, Germany

  ⨯
• Maria Grandoch,

  Roles Investigation, Methodology

  Affiliation Institute for Pharmacology and Clinical Pharmacology, Medical Faculty, HHU Duesseldorf, Duesseldorf, Germany

  ⨯
• Jens W. Fischer,

  Roles Investigation, Methodology

  Affiliation Institute for Pharmacology and Clinical Pharmacology, Medical Faculty, HHU Duesseldorf, Duesseldorf, Germany

  ⨯
• Karl Köhrer,

  Roles Formal analysis, Investigation, Methodology, Validation

  Affiliation Biological and Medical Research Center (BMFZ), HHU, Duesseldorf, Germany

  ⨯
• René Deenen,

  Roles Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Biological and Medical Research Center (BMFZ), HHU, Duesseldorf, Germany

  ⨯
• Klaus Unfried,

  Roles Formal analysis, Investigation, Methodology, Supervision

  Affiliation Environmentally-induced Skin and Lung Aging, IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
• Joachim Altschmied ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: juhae001@uni-duesseldorf.de (JH); joalt001@uni-duesseldorf.de (JA)

  ¶‡ JA and JH also contributed equally to this work.

  Affiliation Core Unit Biosafety Level 2 Laboratory, IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  ⨯
•  [ ... ],
• Judith Haendeler

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: juhae001@uni-duesseldorf.de (JH); joalt001@uni-duesseldorf.de (JA)

  ¶‡ JA and JH also contributed equally to this work.

  Affiliation Heisenberg-group—Environmentally-induced Cardiovascular Degeneration, Medical Faculty, HHU Duesseldorf and IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany

  http://orcid.org/0000-0001-8507-4540

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