Cell Fate Decision as High-Dimensional Critical State Transition

Mitra Mojtahedi; Alexander Skupin; Joseph Zhou; Ivan G. Castaño; Rebecca Y. Y. Leong-Quong; Hannah Chang; Kalliopi Trachana; Alessandro Giuliani; Sui Huang

doi:10.1371/journal.pbio.2000640

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Open Access

Peer-reviewed

Research Article

Cell Fate Decision as High-Dimensional Critical State Transition

Mitra Mojtahedi ,

Contributed equally to this work with: Mitra Mojtahedi, Alexander Skupin

Roles Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Alexander Skupin ,

Contributed equally to this work with: Mitra Mojtahedi, Alexander Skupin

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations Institute for Systems Biology, Seattle, Washington, United States of America, Luxembourg Centre for Systems Biomedicine, Esch-sur Alzette, Luxembourg
⨯
Joseph Zhou,

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Ivan G. Castaño,

Roles Investigation

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Corporación Parque Explora, Department of innovation and design, Medellin, Colombia
⨯
Rebecca Y. Y. Leong-Quong,

Roles Methodology, Project administration, Resources

Affiliation Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
⨯
Hannah Chang,

Roles Investigation

Affiliation 5AM Ventures, Menlo Park, California, United States of America
⨯
Kalliopi Trachana,

Roles Data curation, Investigation, Validation

Affiliation Institute for Systems Biology, Seattle, Washington, United States of America
⨯
Alessandro Giuliani,

Roles Formal analysis, Writing – review & editing

Affiliation Environment and Health Department, Istituto Superiore di Sanità, Roma, Italy
⨯
Sui Huang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sui.huang@systemsbiology.org

Affiliations Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada, Institute for Systems Biology, Seattle, Washington, United States of America
⨯

Cell Fate Decision as High-Dimensional Critical State Transition

Mitra Mojtahedi,
Alexander Skupin,
Joseph Zhou,
Ivan G. Castaño,
Rebecca Y. Y. Leong-Quong,
Hannah Chang,
Kalliopi Trachana,
Alessandro Giuliani,
Sui Huang

Published: December 27, 2016
https://doi.org/10.1371/journal.pbio.2000640
See the preprint

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Cell differentiation
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