Interplay between BRCA1 and RHAMM Regulates Epithelial Apicobasal Polarization and May Influence Risk of Breast Cancer

• Christopher A. Maxwell ,

  * E-mail: cmaxwell@cfri.ubc.ca (CAM); mapujana@ico.scs.es (MAP)

  Current address: Department of Pediatrics, Child and Family Research Institute, Vancouver, British Columbia, Canada

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Javier Benítez,

  Affiliations Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain, Biomedical Research Centre Network for Rare Diseases, Spain

  ⨯
• Laia Gómez-Baldó,

  Affiliations Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain, Biomedical Research Centre Network for Epidemiology and Public Health, Spain

  ⨯
• Ana Osorio,

  Affiliations Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain, Biomedical Research Centre Network for Rare Diseases, Spain

  ⨯
• Núria Bonifaci,

  Affiliations Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain, Biomedical Research Centre Network for Epidemiology and Public Health, Spain, Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
• Ricardo Fernández-Ramires,

  Affiliations Human Cancer Genetics Programme, Spanish National Cancer Research Centre, Madrid, Spain, Biomedical Research Centre Network for Rare Diseases, Spain

  ⨯
• Sylvain V. Costes,

  Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

  ⨯
• Elisabet Guinó,

  Affiliations Biomedical Research Centre Network for Epidemiology and Public Health, Spain, Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
• Helen Chen,

  Affiliation Child and Family Research Institute, Vancouver, British Columbia, Canada

  ⨯
• Gareth J. R. Evans,

  Affiliation Child and Family Research Institute, Vancouver, British Columbia, Canada

  ⨯
• Pooja Mohan,

  Affiliation Child and Family Research Institute, Vancouver, British Columbia, Canada

  ⨯
• Isabel Català,

  Affiliation Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
• Anna Petit,

  Affiliation Department of Pathology, University Hospital of Bellvitge, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
• Helena Aguilar,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Alberto Villanueva,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Alvaro Aytes,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Jordi Serra-Musach,

  Affiliations Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain, Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
• Gad Rennert,

  Affiliation CHS National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Flavio Lejbkowicz,

  Affiliation CHS National Cancer Control Center, Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel

  ⨯
• Paolo Peterlongo,

  Affiliation Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, and IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

  ⨯
• Siranoush Manoukian,

  Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

  ⨯
• Bernard Peissel,

  Affiliation Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

  ⨯
• Carla B. Ripamonti,

  Affiliations Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, and IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy, Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy

  ⨯
• Bernardo Bonanni,

  Affiliation Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy

  ⨯
• Alessandra Viel,

  Affiliation Division of Experimental Oncology 1, Centro di Riferimento Oncologico, IRCCS, Aviano, Italy

  ⨯
• Anna Allavena,

  Affiliation Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy

  ⨯
• Loris Bernard,

  Affiliation Department of Experimental Oncology, Istituto Europeo di Oncologia, and Consortium for Genomics Technology (Cogentech), Milan, Italy

  ⨯
• Paolo Radice,

  Affiliation Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori, and IFOM Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

  ⨯
• Eitan Friedman,

  Affiliations The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel

  ⨯
• Bella Kaufman,

  Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

  ⨯
• Yael Laitman,

  Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

  ⨯
• Maya Dubrovsky,

  Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

  ⨯
• Roni Milgrom,

  Affiliation The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel

  ⨯
• Anna Jakubowska,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Cezary Cybulski,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Bohdan Gorski,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Katarzyna Jaworska,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Katarzyna Durda,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Grzegorz Sukiennicki,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Jan Lubiński,

  Affiliation International Hereditary Cancer Centre, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

  ⨯
• Yin Yao Shugart,

  Affiliation Unit of Statistical Genetics, Division of Intramural Research Program, National Institute of Mental Health, National Institute of Health, Bethesda, Maryland, United States of America

  ⨯
• Susan M. Domchek,

  Affiliation Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Richard Letrero,

  Affiliation Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Barbara L. Weber,

  Current address: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, United States of America

  Affiliation Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Frans B. L. Hogervorst,

  Affiliation Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

  ⨯
• Matti A. Rookus,

  Affiliation Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, the Netherlands

  ⨯
• J. Margriet Collee,

  Affiliation Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands

  ⨯
• Peter Devilee,

  Affiliation Department of Genetic Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• Marjolijn J. Ligtenberg,

  Affiliation Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands

  ⨯
• Rob B. van der Luijt,

  Affiliation Department of Clinical Molecular Genetics, Utrecht University Medical Center, Utrecht, the Netherlands

  ⨯
• Cora M. Aalfs,

  Affiliation Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands

  ⨯
• Quinten Waisfisz,

  Affiliation Department of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands

  ⨯
• Juul Wijnen,

  Affiliation Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• Cornelis E. P. van Roozendaal,

  Affiliation Department of Clinical Genetics, University Medical Center, Maastricht, the Netherlands

  ⨯
• HEBON,

  Affiliation Hereditary Breast and Ovarian Cancer Group, the Netherlands

  ⨯
• EMBRACE,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Douglas F. Easton,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Susan Peock,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Margaret Cook,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Clare Oliver,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Debra Frost,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Patricia Harrington,

  Affiliation Department of Oncology, University of Cambridge, Cambridge, United Kingdom

  ⨯
• D. Gareth Evans,

  Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

  ⨯
• Fiona Lalloo,

  Affiliation Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom

  ⨯
• Rosalind Eeles,

  Affiliation The Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Surrey, United Kingdom

  ⨯
• Louise Izatt,

  Affiliation Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom

  ⨯
• Carol Chu,

  Affiliation Yorkshire Regional Genetics Service, St. James's Hospital, Leeds, United Kingdom

  ⨯
• Diana Eccles,

  Affiliation Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, United Kingdom

  ⨯
• Fiona Douglas,

  Affiliation Institute of Human Genetics, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom

  ⨯
• Carole Brewer,

  Affiliation Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom

  ⨯
• Heli Nevanlinna,

  Affiliation Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

  ⨯
• Tuomas Heikkinen,

  Affiliation Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland

  ⨯
• Fergus J. Couch,

  Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Noralane M. Lindor,

  Affiliation Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Xianshu Wang,

  Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

  ⨯
• Andrew K. Godwin,

  Affiliation Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America

  ⨯
• Maria A. Caligo,

  Affiliation Section of Genetic Oncology, Department of Oncology, University of Pisa, and Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy

  ⨯
• Grazia Lombardi,

  Affiliation Section of Genetic Oncology, Department of Oncology, University of Pisa, and Department of Laboratory Medicine, University Hospital of Pisa, Pisa, Italy

  ⨯
• Niklas Loman,

  Affiliation Department of Oncology, Lund University Hospital, Lund, Sweden

  ⨯
• Per Karlsson,

  Affiliation Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden

  ⨯
• Hans Ehrencrona,

  Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

  ⨯
• Anna von Wachenfeldt,

  Affiliation Department of Oncology, Karolinska University Hospital, Stockholm, Sweden

  ⨯
• SWE-BRCA,

  Affiliation Swedish Breast Cancer Study, Sweden

  ⨯
• Rosa Bjork Barkardottir,

  Affiliation Department of Pathology, Landspitali-University Hospital, Reykjavik, Iceland

  ⨯
• Ute Hamann,

  Affiliation Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany

  ⨯
• Muhammad U. Rashid,

  Affiliation Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum, Heidelberg, Germany, and Department of Basic Sciences, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan

  ⨯
• Adriana Lasa,

  Affiliation Genetic Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Catalonia, Spain

  ⨯
• Trinidad Caldés,

  Affiliation Molecular Oncology Laboratory, Hospital Clínico San Carlos, Madrid, Spain

  ⨯
• Raquel Andrés,

  Affiliation Medical Oncology Division, Hospital Clínico de Zaragoza, Zaragoza, Spain

  ⨯
• Michael Schmitt,

  Affiliation Department of Internal Medicine III, University of Rostock, Rostock, Germany

  ⨯
• Volker Assmann,

  Affiliation Center for Experimental Medicine, Institute of Tumor Biology, University Hospital Hamburg–Eppendorf, Hamburg, Germany

  ⨯
• Kristen Stevens,

  Affiliation Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Kenneth Offit,

  Affiliation Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America

  ⨯
• João Curado,

  Affiliation Bioinformatics and Genomics Group, Centre for Genomic Regulation (CRG), Biomedical Research Park of Barcelona (PRBB), Barcelona, Catalonia, Spain

  ⨯
• Hagen Tilgner,

  Affiliation Bioinformatics and Genomics Group, Centre for Genomic Regulation (CRG), Biomedical Research Park of Barcelona (PRBB), Barcelona, Catalonia, Spain

  ⨯
• Roderic Guigó,

  Affiliation Bioinformatics and Genomics Group, Centre for Genomic Regulation (CRG), Biomedical Research Park of Barcelona (PRBB), Barcelona, Catalonia, Spain

  ⨯
• Gemma Aiza,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Joan Brunet,

  Affiliation Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

  ⨯
• Joan Castellsagué,

  Affiliation Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

  ⨯
• Griselda Martrat,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Ander Urruticoechea,

  Affiliation Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain

  ⨯
• Ignacio Blanco,

  Affiliation Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

  ⨯
• Laima Tihomirova,

  Affiliation Latvian Biomedical Research and Study Center, Riga, Latvia

  ⨯
• David E. Goldgar,

  Affiliation Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America

  ⨯
• Saundra Buys,

  Affiliation Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, United States of America

  ⨯
• Esther M. John,

  Affiliation Cancer Prevention Institute of California, Fremont, California, United States of America

  ⨯
• Alexander Miron,

  Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Surgery, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Melissa Southey,

  Affiliation Centre for Molecular, Environmental, Genetic and Analytic (MEGA) Epidemiology, Melbourne School of Population Health, The University of Melbourne, Victoria, Australia

  ⨯
• Mary B. Daly,

  Affiliation Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America

  ⨯
• BCFR,

  Affiliation Breast Cancer Family Registry, United States of America

  ⨯
• Rita K. Schmutzler,

  Affiliation Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology, University of Cologne, Cologne, Germany

  ⨯
• Barbara Wappenschmidt,

  Affiliation Center for Familial Breast and Ovarian Cancer and Center of Integrated Oncology, University of Cologne, Cologne, Germany

  ⨯
• Alfons Meindl,

  Affiliation Department of Obstetrics and Gynaecology, Klinikum rechts der Isar, Technical University, Munich, Germany

  ⨯
• Norbert Arnold,

  Affiliation Division of Oncology, Department of Gynaecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel, Germany

  ⨯
• Helmut Deissler,

  Affiliation Department of Obstetrics and Gynecology, Ulm University, Ulm, Germany

  ⨯
• Raymonda Varon-Mateeva,

  Affiliation Institut für Humangenetik, Charité-Universitätsmedizin Berlin, Berlin, Germany

  ⨯
• Christian Sutter,

  Affiliation Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany

  ⨯
• Dieter Niederacher,

  Affiliation Division of Molecular Genetics, Department of Gynaecology and Obstetrics, Clinical Center University of Düsseldorf, Düsseldorf, Germany

  ⨯
• Evgeny Imyamitov,

  Affiliation N. N. Petrov Institute of Oncology, Saint-Petersburg, Russian Federation

  ⨯
• Olga M. Sinilnikova,

  Affiliations Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Centre Hospitalier Universitaire de Lyon, Centre Léon Bérard, Lyon, France, Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

  ⨯
• Dominique Stoppa-Lyonne,

  Affiliation INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France

  ⨯
• Sylvie Mazoyer,

  Affiliation Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

  ⨯
• Carole Verny-Pierre,

  Affiliation Equipe labellisée LIGUE 2008, UMR5201 CNRS, Centre Léon Bérard, Université de Lyon, Lyon, France

  ⨯
• Laurent Castera,

  Affiliation INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France

  ⨯
• Antoine de Pauw,

  Affiliation INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes, Paris, France

  ⨯
• Yves-Jean Bignon,

  Affiliation Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France

  ⨯
• Nancy Uhrhammer,

  Affiliation Département d'Oncogénétique, Centre Jean Perrin, Université de Clermont-Ferrand, Clermont-Ferrand, France

  ⨯
• Jean-Philippe Peyrat,

  Affiliation Laboratoire d'Oncologie Moléculaire Humaine, Centre Oscar Lambret, Lille, France

  ⨯
• Philippe Vennin,

  Affiliation Consultation d'Oncogénétique, Centre Oscar Lambret, Lille, France

  ⨯
• Sandra Fert Ferrer,

  Affiliation Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France

  ⨯
• Marie-Agnès Collonge-Rame,

  Affiliation Service de Génétique-Histologie-Biologie du Développement et de la Reproduction, Centre Hospitalier Universitaire de Besançon, Besançon, France

  ⨯
• Isabelle Mortemousque,

  Affiliation Service de Génétique, Centre Hospitalier Universitaire Bretonneau, Tours, France

  ⨯
• GEMO Study Collaborators,

  Affiliation GEMO Study (Genetics Network “Groupe Génétique et Cancer”), Fédération Nationale des Centres de Lutte Contre le Cancer, France

  ⨯
• Amanda B. Spurdle,

  Affiliation Queensland Institute of Medical Research, Brisbane, Australia

  ⨯
• Jonathan Beesley,

  Affiliation Queensland Institute of Medical Research, Brisbane, Australia

  ⨯
• Xiaoqing Chen,

  Affiliation Queensland Institute of Medical Research, Brisbane, Australia

  ⨯
• Sue Healey,

  Affiliation Queensland Institute of Medical Research, Brisbane, Australia

  ⨯
• kConFab,

  Affiliation The Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Institute, East Melbourne, Australia

  ⨯
• Mary Helen Barcellos-Hoff,

  Current address: Department of Radiation Oncology, New York University Langone School of Medicine, New York, New York, United States of America

  Affiliation Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

  ⨯
• Marc Vidal,

  Affiliation Center for Cancer Systems Biology (CCSB) and Department of Cancer Biology, Dana-Farber Cancer Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

  ⨯
• Stephen B. Gruber,

  Affiliation Department of Internal Medicine, Epidemiology, Human Genetics, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Conxi Lázaro,

  Affiliation Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

  ⨯
• Gabriel Capellá,

  Affiliation Genetic Counseling and Hereditary Cancer Programme, Catalan Institute of Oncology, IDIBELL and Girona Biomedical Research Institute (IdIBGi), Catalonia, Spain

  ⨯
• Lesley McGuffog,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Katherine L. Nathanson,

  Affiliation Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

  ⨯
• Antonis C. Antoniou,

  Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

  ⨯
• Georgia Chenevix-Trench,

  Affiliation Queensland Institute of Medical Research, Brisbane, Australia

  ⨯
• Markus C. Fleisch,

  Affiliation Department of Obstetrics and Gynaecologie, Heinrich-Heine-University, Duesseldorf, Germany

  ⨯
• Víctor Moreno,

  Affiliations Biomedical Research Centre Network for Epidemiology and Public Health, Spain, Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

  ⨯
•  [ ... ],
• Miguel Angel Pujana

  * E-mail: cmaxwell@cfri.ubc.ca (CAM); mapujana@ico.scs.es (MAP)

  Affiliations Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet, Catalonia, Spain, Biomedical Research Centre Network for Epidemiology and Public Health, Spain, Biomarkers and Susceptibility Unit, Catalan Institute of Oncology, IDIBELL, L'Hospitalet, Catalonia, Spain

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