About the Authors

Satoko Sakamoto

Contributed equally to this work with: Satoko Sakamoto, Dean Thumkeo

Roles Conceptualization, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

Dean Thumkeo

Contributed equally to this work with: Satoko Sakamoto, Dean Thumkeo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

d.thumkeo@mfour.med.kyoto-u.ac.jp (DT); snaru@mfour.med.kyoto-u.ac.jp (SN)

Affiliations Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Hiroshi Ohta

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Zhen Zhang

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Mechanobiology Institute, National University of Singapore, Singapore

Shuangru Huang

Roles Investigation, Methodology

Affiliation Mechanobiology Institute, National University of Singapore, Singapore

Pakorn Kanchanawong

Roles Supervision, Writing – review & editing

Affiliations Mechanobiology Institute, National University of Singapore, Singapore, Department of Biomedical Engineering, National University of Singapore, Singapore

Takayoshi Fuu

Roles Investigation, Methodology

Affiliation Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

Sadanori Watanabe

Roles Investigation, Methodology, Writing – review & editing

Current address: Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America

Affiliation Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan

Kentaro Shimada

Roles Investigation, Methodology

Affiliation Research Institute for Microbial Disease, Osaka University, Osaka, Japan

Yoshitaka Fujihara

Roles Investigation, Methodology

Affiliation Research Institute for Microbial Disease, Osaka University, Osaka, Japan

Shosei Yoshida

Roles Supervision

Affiliation National Institute for Basic Biology, Okazaki, Japan

Masahito Ikawa

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Research Institute for Microbial Disease, Osaka University, Osaka, Japan

Naoki Watanabe

Roles Supervision, Writing – review & editing

Affiliations Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan, Laboratory of Single-Molecule Cell Biology, Kyoto University Graduate School of Biostudies, Kyoto, Japan

Mitinori Saitou

Roles Supervision, Writing – review & editing

Affiliation Department of Anatomy and Cell Biology, Kyoto University Graduate School of Medicine, Kyoto, Japan

Shuh Narumiya

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

d.thumkeo@mfour.med.kyoto-u.ac.jp (DT); snaru@mfour.med.kyoto-u.ac.jp (SN)

Affiliations Medical Innovation Center, Kyoto University Graduate School of Medicine, Kyoto, Japan, Department of Drug Discovery Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Competing Interests

DT and SN were supported by the Coordination Fund from MEXT and Astellas Pharma. SN is a scientific advisor to Astellas Pharma. Other authors declare that they have no conflicts of interest.