MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunopathology and immunosuppression

• Christopher R. Shaler,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Joshua Choi,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Patrick T. Rudak,

  Roles Investigation, Methodology, Validation

  Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Arash Memarnejadian,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Peter A. Szabo,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Western University, London, Ontario, Canada

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• Mauro E. Tun-Abraham,

  Roles Resources

  Affiliation Division of General Surgery, Department of Surgery, Western University, London, Ontario, Canada

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• Jamie Rossjohn,

  Roles Methodology, Resources

  Affiliations Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom

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• Alexandra J. Corbett,

  Roles Investigation, Methodology, Resources, Validation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia

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• James McCluskey,

  Roles Methodology, Resources

  Affiliation Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia

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• John K. McCormick,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, Western University, London, Ontario, Canada, Centre for Human Immunology, Western University, London, Ontario, Canada, Lawson Health Research Institute, London, Ontario, Canada

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• Olivier Lantz,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Laboratoire d'Immunologie and INSERM U932, Institut Curie, Paris, France

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• Roberto Hernandez-Alejandro,

  Roles Funding acquisition, Investigation, Resources

  Affiliations Division of General Surgery, Department of Surgery, Western University, London, Ontario, Canada, Division of Transplantation, Department of Surgery, University of Rochester Medical Center, Rochester, New York, United States of America

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• S.M. Mansour Haeryfar

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft

  * E-mail: Mansour.Haeryfar@schulich.uwo.ca

  Affiliations Department of Microbiology and Immunology, Western University, London, Ontario, Canada, Centre for Human Immunology, Western University, London, Ontario, Canada, Lawson Health Research Institute, London, Ontario, Canada, Division of Clinical Immunology and Allergy, Department of Medicine, Western University, London, Ontario, Canada

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