About the Authors

Scott J. Callahan

Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Yvette A. Luyten

Affiliation New England Biolabs Inc., Ipswich, Massachusetts, United States of America

Yogesh K. Gupta

Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Geoffrey G. Wilson

Affiliation New England Biolabs Inc., Ipswich, Massachusetts, United States of America

Richard J. Roberts

Affiliation New England Biolabs Inc., Ipswich, Massachusetts, United States of America

Richard D. Morgan

morgan@neb.com (RDM); aneel.aggarwal@mssm.edu (AKA)

Affiliation New England Biolabs Inc., Ipswich, Massachusetts, United States of America

Aneel K. Aggarwal

morgan@neb.com (RDM); aneel.aggarwal@mssm.edu (AKA)

Affiliation Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, New York, United States of America

Competing Interests

YAL, GGW, RJR, and RDM are employees and shareholders of New England Biolabs, Inc.

Author Contributions

Conceived and designed the experiments: RJR GGW RDM AKA. Performed the experiments: SJC YAL RDM. Analyzed the data: SJC YAL YKG GGW RJR RDM AKA. Wrote the paper: SJC YKG GGW RJR RDM AKA.