About the Authors

Cassandra Coburn

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Erik Allman

Affiliation Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America

Parag Mahanti

Affiliation Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America

Alexandre Benedetto

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Filipe Cabreiro

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Zachary Pincus

Affiliation Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

Filip Matthijssens

Affiliation Department of Biology, Ghent University, Ghent, Belgium

Caroline Araiz

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Abraham Mandel

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Manolis Vlachos

Affiliation Institute of Molecular Biology and Biotechnology, University of Crete, Heraklion, Crete, Greece

Sally-Anne Edwards

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Grahame Fischer

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Alexander Davidson

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Rosina E. Pryor

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Ailsa Stevens

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Frank J. Slack

Affiliation Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, United States of America

Nektarios Tavernarakis

Affiliation Institute of Molecular Biology and Biotechnology, University of Crete, Heraklion, Crete, Greece

Bart P. Braeckman

Affiliation Department of Biology, Ghent University, Ghent, Belgium

Frank C. Schroeder

Affiliation Boyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York, United States of America

Keith Nehrke

Affiliations Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York, United States of America, Department of Medicine, University of Rochester Medical Center, Rochester, New York, United States of America

David Gems

david.gems@ucl.ac.uk

Affiliation Institute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CC DG KN PM AB FC. Performed the experiments: CC AD SAE AS FS ZP PM BB FM AM GF EA KN MV NT AB CA FC REP. Analyzed the data: CC DG KN EA PM FS BB FM MV NT AB. Contributed reagents/materials/analysis tools: PM FS EA FJS KN FM BB. Wrote the paper: CC DG KN. AS worked as an undergraduate project student to identify the severity of different Glo mutant phenotypes, consequently allowing us to select glo-1(zu347) as the primary mutant of study.