The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age

Raja Kittappa; Wendy W Chang; Rajeshwar B Awatramani; Ronald D. G McKay

doi:10.1371/journal.pbio.0050325

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Peer-reviewed

Research Article

The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age

Raja Kittappa ,

Contributed equally to this work with: Raja Kittappa, Wendy W Chang

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Wendy W Chang ,

Contributed equally to this work with: Raja Kittappa, Wendy W Chang

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Rajeshwar B Awatramani,

Affiliation Department of Neurology, Northwestern University School of Medicine, Chicago, Illinois, United States of America
⨯
Ronald D. G McKay

*To whom correspondence should be addressed. E-mail: mckay@codon.nih.gov

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

The foxa2 Gene Controls the Birth and Spontaneous Degeneration of Dopamine Neurons in Old Age

Raja Kittappa,
Wendy W Chang,
Rajeshwar B Awatramani,
Ronald D. G McKay

Published: December 11, 2007
https://doi.org/10.1371/journal.pbio.0050325

About the Authors

Raja Kittappa

Contributed equally to this work with: Raja Kittappa, Wendy W Chang

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Wendy W Chang

Contributed equally to this work with: Raja Kittappa, Wendy W Chang

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Rajeshwar B Awatramani

Affiliation Department of Neurology, Northwestern University School of Medicine, Chicago, Illinois, United States of America

Ronald D. G McKay

*To whom correspondence should be addressed. E-mail: mckay@codon.nih.gov

Affiliation Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RK and WWC conceived and designed the experiments. RK and WWC performed the experiments. RBA contributed reagents/materials/analysis tools. RK and RDGM analyzed the data and wrote the paper.

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Dopamine
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Neurons
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Midbrain
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Motor neurons
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Neuronal differentiation
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Mice
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Parkinson disease
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