About the Authors

Orion D Weiner

To whom correspondence should be addressed. E-mail: orion.weiner@ucsf.edu (ODW); marc@hms.harvard.edu (MWK)

Affiliations Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America , Cardiovascular Research Institute, University of California San Francisco, San Francisco, California, United States of America

William A Marganski

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Lani F Wu

Affiliations Department of Pharmacology, Southwestern Medical School, Dallas, Texas, United States of America , Green Comprehensive Center for Molecular, Computational, and Systems Biology, Southwestern Medical School, Dallas, Texas, United States of America

Steven J Altschuler

Affiliations Department of Pharmacology, Southwestern Medical School, Dallas, Texas, United States of America , Green Comprehensive Center for Molecular, Computational, and Systems Biology, Southwestern Medical School, Dallas, Texas, United States of America

Marc W Kirschner

To whom correspondence should be addressed. E-mail: orion.weiner@ucsf.edu (ODW); marc@hms.harvard.edu (MWK)

Affiliation Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

ODW, WAM, and MWK conceived and designed the experiments. ODW and WAM performed the experiments. ODW, WAM, LFW, and SJA analyzed the data and contributed reagents/materials/analysis tools. ODW and MWK wrote the paper.