PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Julia W Pridgeon; James A Olzmann; Lih-Shen Chin; Lian Li

doi:10.1371/journal.pbio.0050172

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Open Access

Peer-reviewed

Research Article

PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Julia W Pridgeon ,

Contributed equally to this work with: Julia W Pridgeon, James A Olzmann

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
James A Olzmann ,

Contributed equally to this work with: Julia W Pridgeon, James A Olzmann

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Lih-Shen Chin ,

*To whom correspondence should be addressed. E-mail: chinl@pharm.emory.edu (LSC); lianli@pharm.emory.edu (LL)

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Lian Li

*To whom correspondence should be addressed. E-mail: chinl@pharm.emory.edu (LSC); lianli@pharm.emory.edu (LL)

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

PINK1 Protects against Oxidative Stress by Phosphorylating Mitochondrial Chaperone TRAP1

Julia W Pridgeon,
James A Olzmann,
Lih-Shen Chin,
Lian Li

Published: June 19, 2007
https://doi.org/10.1371/journal.pbio.0050172

About the Authors

Julia W Pridgeon

Contributed equally to this work with: Julia W Pridgeon, James A Olzmann

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

James A Olzmann

Contributed equally to this work with: Julia W Pridgeon, James A Olzmann

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

Lih-Shen Chin

*To whom correspondence should be addressed. E-mail: chinl@pharm.emory.edu (LSC); lianli@pharm.emory.edu (LL)

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

Lian Li

*To whom correspondence should be addressed. E-mail: chinl@pharm.emory.edu (LSC); lianli@pharm.emory.edu (LL)

Affiliation Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

All authors conceived and designed the experiments. JWP, JAO, and LSC performed the experiments and analyzed the data. LSC contributed reagents/materials/analysis tools. JWP, JAO, and LL wrote the paper.

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Mitochondria
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Phosphorylation
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Apoptosis
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Transfection
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Immunoprecipitation
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Parkinson disease
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Small interfering RNA
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Immunoblotting
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