About the Authors

Lars Malmström

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Michael Riffle

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Charlie E. M Strauss

Affiliation Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America

Dylan Chivian

¤ Current address: Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Trisha N Davis

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

Richard Bonneau

Affiliation Department of Biology, Department of Computer Science, and Center for Comparative Functional Genomics, New York University, New York, New York, United States of America

David Baker

To whom correspondence should be addressed. E-mail: dabaker@u.washington.edu

Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America , Howard Hughes Medical Institute, University of Washington, Seattle, Washington, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

LM, TND, RB, and DB conceived and designed the experiments. LM performed the experiments. LM, RB, and DB analyzed the data. LM, MR, CEMS, and DC contributed reagents/materials/analysis tools. LM, RB, and DB wrote the paper.