A Burst-Based “Hebbian” Learning Rule at Retinogeniculate Synapses Links Retinal Waves to Activity-Dependent Refinement

Daniel A Butts; Patrick O Kanold; Carla J Shatz

doi:10.1371/journal.pbio.0050061

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Open Access

Peer-reviewed

Research Article

A Burst-Based “Hebbian” Learning Rule at Retinogeniculate Synapses Links Retinal Waves to Activity-Dependent Refinement

Daniel A Butts ,

*To whom correspondence should be addressed. E-mail: dab2024@med.cornell.edu

¤ Current address: Institute of Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, United States of America

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Patrick O Kanold,

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Carla J Shatz

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Burst-Based “Hebbian” Learning Rule at Retinogeniculate Synapses Links Retinal Waves to Activity-Dependent Refinement

Daniel A Butts,
Patrick O Kanold,
Carla J Shatz

Published: March 6, 2007
https://doi.org/10.1371/journal.pbio.0050061

About the Authors

Daniel A Butts

*To whom correspondence should be addressed. E-mail: dab2024@med.cornell.edu

¤ Current address: Institute of Computational Biomedicine, Weill Medical College of Cornell University, New York, New York, United States of America

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

Patrick O Kanold

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

Carla J Shatz

Affiliation Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

CJS guided the project. DAB conceived and designed the experiments, performed the experiments, and analyzed the data. POK contributed reagents/materials/analysis tools. DAB wrote the paper.

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Action potentials
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Eyes
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Retinal ganglion cells
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Neurons
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Synapses
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Synaptic plasticity
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Retina
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Depolarization
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