About the Authors

R. Grace Zhai

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Yu Cao

Affiliation Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

P. Robin Hiesinger

¤ Current address: Department of Physiology and Green Center Division for Systems Biology, UT Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Yi Zhou

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Sunil Q Mehta

Affiliation Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America

Karen L Schulze

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Patrik Verstreken

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America

Hugo J Bellen

To whom correspondence should be addressed. E-mail: hbellen@bcm.edu

Affiliations Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas, United States of America , Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America , Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

RGZ and HJB conceived and designed the experiments. RGZ, YC, PRH, YZ, SQM, KLS, and PV performed the experiments. RGZ, PRH, and HJB analyzed the data. RGZ, PRH, SQM, KLS, and PV contributed reagents/materials/analysis tools. RGZ, PRH, KLS, and HJB wrote the paper.