About the Authors

Unnur Styrkarsdottir

To whom correspondence should be addressed. E-mail: unnur.styrkarsdottir@decode.is (US), Email: gunnars@landspitali.is (GS), Email: kari.stefansson@decode.is (KS)

Affiliation deCODE Genetics, Reykjavik, Iceland

Jean-Baptiste Cazier

Affiliation deCODE Genetics, Reykjavik, Iceland

Augustine Kong

Affiliation deCODE Genetics, Reykjavik, Iceland

Ottar Rolfsson

Affiliation deCODE Genetics, Reykjavik, Iceland

Helene Larsen

Affiliation deCODE Genetics, Reykjavik, Iceland

Emma Bjarnadottir

Affiliation deCODE Genetics, Reykjavik, Iceland

Vala D Johannsdottir

Affiliation deCODE Genetics, Reykjavik, Iceland

Margret S Sigurdardottir

Affiliation deCODE Genetics, Reykjavik, Iceland

Yu Bagger

Affiliation Center for Clinical and Basic Research A/S, Ballerup, Denmark

Claus Christiansen

Affiliation Center for Clinical and Basic Research A/S, Ballerup, Denmark

Inga Reynisdottir

Affiliation deCODE Genetics, Reykjavik, Iceland

Struan F. A Grant

Affiliation deCODE Genetics, Reykjavik, Iceland

Kristjan Jonasson

Affiliation deCODE Genetics, Reykjavik, Iceland

Michael L Frigge

Affiliation deCODE Genetics, Reykjavik, Iceland

Jeffrey R Gulcher

Contributed equally to this work with: Jeffrey R Gulcher, Kari Stefansson

Affiliation deCODE Genetics, Reykjavik, Iceland

Gunnar Sigurdsson

To whom correspondence should be addressed. E-mail: unnur.styrkarsdottir@decode.is (US), Email: gunnars@landspitali.is (GS), Email: kari.stefansson@decode.is (KS)

Affiliation National University Hospital, Reykjavik, Iceland

Kari Stefansson

Contributed equally to this work with: Jeffrey R Gulcher, Kari Stefansson

To whom correspondence should be addressed. E-mail: unnur.styrkarsdottir@decode.is (US), Email: gunnars@landspitali.is (GS), Email: kari.stefansson@decode.is (KS)

Affiliation deCODE Genetics, Reykjavik, Iceland

Competing Interests

The authors have declared that conflicts of interest exist. Some authors have stocks in deCODE Genetics as well as equity interests. Some of the work described here is subject to patent filings for diagnostics purposes with US, J-BC, and VDJ as inventors.

Author Contributions

US, J-BC, AK, HL, KJ, JRG, GS, and KS conceived and designed the experiments. US, OR, HL, EB, VDJ, and MSS performed the experiments. US, J-BC, AK, HL, KJ, and MLF analyzed the data. YB, CC, GS, and KS contributed reagents/materials/analysis tools. US, J-BC, AK, HL, MLF, JRG, and KS wrote the paper.