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Noradrenaline for effort... and dopamine for reward

October 12, 2020

Noradrenaline for effort... and dopamine for reward

Nicolas Borderies, Pauline Bornert, Sophie Gilardeau and Sebastien Bouret, using pharmacology in rhesus monkeys performing a complex effort/reward task, show that noradrenaline plays a specific role in effort, complementing the well-known role of dopamine in reward.

Image credit: Wikimedia Commons users Vaccinationist & Jynto

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

10/13/2020

Research Article

The phage resistance landscape

To map the landscape of genetic determinants important in host-phage interactions, Vivek Mutalik, Adam Arkin and co-workers apply unbiased high-throughput loss-of-function and gain-of-function screening methods to two different strains of E. coli. These methods rapidly identify phage receptors and other host factors (both novel and previously described) involved in resistance across a wide panel of 13 dsDNA phages.

Image credit: pbio.3000877

The phage resistance landscape

Recently Published Articles

Current Issue

Current Issue September 2020

10/16/2020

perspective

COVID-19 and traditional academic reward structures

The COVID-19 pandemic has emphasized the importance of open and collaborative analytical research projects, which are generally overlooked by traditional academic metrics. Adam Kucharski, Sebastian Funk and Rosalind Eggo maintain that to increase the impact and sustainability of modern science, it will be crucial to ensure that these non-traditional scholarly outputs – and the people who do them – are valued in academia.

Image credit: Wikimedia Commons user Ytoyoda

COVID-19 and traditional academic reward structures

10/16/2020

Research Article

Evolution of thermal sensitivity

Whether and how the thermal sensitivities of biological traits respond to different environments is a topic of active debate. Dimitrios-Georgios Kontopoulos, Samraat Pawar and colleagues show that the thermal sensitivity of population growth rate does not evolve in a gradual manner across microbes, but often undergoes rapid adaptive evolution.

Image credit: pbio.3000894

Evolution of thermal sensitivity

10/14/2020

Primer

Granularity in the circadian clock

A recent PLOS Biology paper shows that clonal cell populations are themselves a collection heterogeneous cellular circadian clocks; this Primer by Martha Merrow and Mary Harrington explores the implications, proposing that the phase of entrainment of biological clocks (to time of day or to season) is granular, built from the contributions of individual cells.

Granularity in the circadian clock

Image credit: Flirk user sf-dvs, Subasis Mahat, pbio.3000927

10/13/2020

Research Article

Basal ganglia synchrony to inhibit thalamus

Task-related activity in the ventral thalamus is often assumed to be triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. Paired unit recordings from basal ganglia and thalamus in nonhuman primates, by Bettina Schwab, Robert Turner and co-workers, reveal the absence of strong gating or rebound during a trained reaching task; simulations suggest the need for basal ganglia synchrony to effectively inhibit thalamus.

Basal ganglia synchrony to inhibit thalamus

Image credit: pbio.3000829

10/12/2020

Research Article

Early warning of invasive plant pathogens.

By linking a mathematical model of pest spread with a computational optimisation routine, this study identifies where to look for invasive pests if we wish to detect them at an early stage.

Early warning of invasive plant pathogens.

Image credit: T.R. Gottwald and S.M. Garnsey

04/08/2020

Research Article

Survey of the mononuclear phagocyte system

A comprehensive network analysis of transcriptomic data reveals the close relationships between tissue-resident cells of the mononuclear phagocyte system and questions the utility of surface markers to define lineages, functions, or subpopulations.

Survey of the mononuclear phagocyte system

Image credit: pbio.3000859

10/07/2020

Methods and Resources

Multiplex detection of SARS-CoV-2 RNA

The current RT-qPCR assay recommended for SARS-CoV-2 testing in the US requires analysis of three genomic targets per sample. A multiplex PCR saves both reagents and labor while accurately detecting SARS-CoV-2 RNA.

Multiplex detection of SARS-CoV-2 RNA

Image credit: pbio.3000867

10/05/2020

Research Article

Mites, Notch and IBD

Dimerization of the signaling protein Notch contributes to intestinal homeostasis. Mite infestation exacerbates all phenotypes, and triggers marginal zone B cell hyperproliferation in mutant animals, with implications for the role of dust mite allergies in human IBD and cancer.

Mites, Notch and IBD

Image credit: CSIRO ScienceImage

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