07/11/2019
Research Article
Ora Hazak, Elad Mamon, Shaul Yalovsky and colleagues show that an auxin-regulated calcium-dependent signal transducer, CMI1, regulates auxin responses and root development, providing a basis for cross talk between auxin and calcium signaling in plants.
Image credit: pbio.3000085
Current Issue June 2019
07/09/2019
Research Article
Irène Nicolas, Valérie Bordeau, Brice Felden and co-authors used a naturally occurring bacterial toxin to inspire the design of novel cyclic heptapseudopeptide antibiotics with limited resistance; these new peptidomimetics are active against gram-negative and -positive multi-resistant ESKAPE pathogens.
Image credit: pbio.3000337
07/08/2019
Research Article
A global view of the Hsp90 chaperone interactome in the fungal pathogen Candida albicans, by Teresa O’Meara, Leah Cowen and co-workers, reveals the dynamic role of Hsp90 in response to environmental perturbations, and highlights a novel connection between Hsp90 and the regulation of mRNA-associated protein granules.
Image credit: pbio.3000358
07/11/2019
Research Article
Liya Ma, Stefan Everling and colleagues show that reversible deactivation of the dorsal anterior cingulate cortex — an area of the cognitive control network — impairs rule maintenance but not rule switching per se, and disrupts task-related oscillatory activities in the dorsolateral prefrontal cortex — another area of the same network.
Image credit:
07/02/2019
Research Article
Behavioral experiments with the spider Agelena labyrinthica, coupled with computational modelling, by Violette Chiara, Felipe Ramon Portugal and Raphael Jeanson, show that an increase in mobility with age drives dispersal in gregarious spiderlings of a solitary species and that the subsequent social isolation triggers aggression.
Image credit: Flickr user Esin Üstün
07/01/2019
Community Page
Katrin Amunts, Jan Bjaalie and co-authors present the Human Brain Project; a European Flagship project with a ten-year horizon aiming to understand the human brain and translate neuroscience knowledge into medicine and technology.
Image credit: pbio.3000344
07/01/2019
Research Article
Type III secretion machines evolved to inject bacterial effector proteins into eukaryotic cells. This study provides insights into the mechanism by which the contact signal is transduced to activate the protein secretion machine.
Image credit: pbio.3000351
07/02/2019
Methods and Resources
Androgenetic haploid embryonic stem cells expressing Cas9 and a medium-scale sgRNA library provide a means to mutate genes at the organism level, here identifying Irx5 as a regulator of bone development.
Image credit: pbio.3000350
07/03/2019
Research Article
Expression of a subset of human genes forms two gradients that capture the processing hierarchy of visual cortex; these gradients emerge at different points during development and distinguish humans from other primates.
Image credit: pbio.3000362
07/03/2019
Methods and Resources
The transcriptomic landscape of the human fetal neural retina and retinal pigment epithelium reveals a tightly regulated spatiotemporal gene expression network of human retinal cells.
Image credit: pbio.3000365
Raquel Lieberman discusses her work on the protein myocilin, implicated in glaucoma, but whose normal function remains unclear after over 20 years.
Susanna Bidgood explores the future of using poxviruses as versatile tools for cell biology research.
Rachel Harding proposes that open notebooks present an opportunity for researchers to showcase their work and rapidly advance science in their field
On the eve of the UN General Assembly meeting on TB, Christoph Grundner urged the need to consider basic research as an essential component of any future anti-TB strategy.
Norman Pace remembers the early days of what became known as "metagenomics," as experienced by the author during his development as a scientist.
Meet Senior Editor Ines Alvarez-Garcia in Krakow, Poland.
June 11-16, 2019
Meet Senior Editor Lauren Richardson in Princeton, NJ.
June 11-13, 2019
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