04/04/2024
Research Article
Hsp70 chaperones preserve protein synthesis by promoting protein folding and preventing its aggregation. Carissa Chan and Eduardo Groisman report a new role of Hsp70 in Salmonella enterica survival during low Mg2+ conditions by binding to the ribosome and reducing protein synthesis.
Image credit: pbio.3002560
Current Issue March 2024
04/01/2024
Short Reports
How does the processing of images with high and low memorability differ in the brain? Benjamin Lahner, Yalda Mohsenzadeh, Caitlin Mullin and Aude Oliva combine fMRI and MEG to show that only images with high memorability scores undergo extended processing late in time throughout the ventral visual stream, including early visual cortex.
Image credit: pbio.3002564
03/28/2024
Update Article
Wolbachia-induced cytoplasmic incompatibility in fruit flies is known to cause embryonic lethality by modifying chromatin integrity in developing sperm. Rupinder Kaur, Seth Bordenstein and co-workers reveal an analogous mechanism in the wMel-transinfected Aedes aegypti mosquitoes that are used to control vector-borne diseases.
Image credit: Rupinder Kaur
03/28/2024
Research Article
The oncoprotein MYCN drives oncogenesis in neuroblastoma by activating genes involved in ribosome biogenesis and protein synthesis, while repressing neuronal differentiation, but the underlying mechanisms are unknown. Zhihui Liu, Carol Thiele and co-authors show that MYCN cooperates with the histone methyltransferase G9a and the WDR5 adaptor to orchestrate global gene transcription.
Image credit: pbio.3002240
03/19/2024
Research Article
The E3 ubiquitin ligase RFDW3 regulates replication fork progression and stability, but how does it achieve this? Maïlyn Yates, Alexandre Maréchal and co-workers reveal that SMARCAL1 is a substrate of RFWD3 and that its ubiquitylation disengages it from RPA, thereby limiting its activity at stalled replication forks and preventing fork collapse.
Image credit: pbio.3002552
03/19/2024
Methods and Resources
Galactose is an important sugar that can fuel glycolysis, but observing its metabolic dynamics in vivo has been difficult to date. Uğurcan Sakizli, Tomomi Takano and Sa Kan Yoo develop a genetically encoded sensor to measure intracellular galactose dynamics in flies.
Image credit: Ugurcan Sakizli
04/05/2024
Perspective
Recent research has revealed that all animals and plants likely require interactions with microbes. Margaret McFall-Ngai argues that while the recognition of this phenomenon is slow in coming, it will impact most, if not all, subdisciplines of biology.
Image credit: pbio.1001783
04/04/2024
Perspective
Exploring the mechanisms that underpin symbiosis requires an understanding of how these complex interactions are maintained in diverse model systems. Benjamin Jenkins discusses how the ciliate protist Paramecium can reveal how emergent endosymbiotic interactions have evolved.
Image credit: pbio.3002563
04/03/2024
Perspective
Environmental bacteria influence many facets of choanoflagellate biology. Arielle Woznica explores why choanoflagellates are an exciting system for considering how symbiotic associations with bacteria may have shaped the early evolution of animals.
Image credit: pbio.3002561
03/22/2024
Perspective
Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of lysosome function. Claudio Bussi and Maximiliano Gutierrez propose a 'lysosome states' concept that links single lysosomes to function.
Image credit: pbio.3002576
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
The green collection explores biological solutions that could be applied to reduce CO2 emissions, get rid of non-degradable plastics, produce food in a sustainable manner or generate energy.
This collection explores potential solutions to mitigate the impacts of human activity on ocean ecosystems to minimize or reverse degradation.
To mark 200 years since the birth of Gregor Mendel, this collection looks back at the impact of his original research and asks how well it stands up to modern views on genetics.
April 29 - 30
Virtually meet Magazine Editor Joanna Clarke (jclarkeplos.org)
May 6 - 8
Meet Senior Editor Richard Hodge (rhodge@plos.org)
May 19 - 24
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
May 29 - Jun 2
Meet Senior Editor Luke Smith (lsmith@plos.org)
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