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Predators Modify Impact of Environmental Temperature

June 10, 2019

Predators Modify Impact of Environmental Temperature

Environmental temperature affects species interactions and ecosystem functions via effects in metabolic rates. This experimental mesocosm study by Jessica Garzke, Stephanie Connor, Ulrich Sommer and Mary O'Connor shows that predators can influence how metabolic responses to temperature affect ecosystem function at larger scales.

Image credit: Flickr NTNU

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PLOS Biology's XV Collection

06/10/2019

Research Article

Actin Wars

Adrien Antkowiak, Alphée Michelot and co-workers use a biomimetic assay involving polystyrene beads to compare the rates of actin assembly on linear and branched networks, revealing how the size of rival actin networks in cells is regulated by their relative capacity to assemble in a common environment.

Image credit: pbio.3000317

Actin Wars

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Current Issue May 2019

06/11/2019

Research Article

An Achilles' Heel for Rhino- and Enteroviruses

Rana Abdelnabi, James Geraets, Sarah Butcher, Johan Neyts and colleagues identify a novel druggable pocket present in most enterovirus and rhinovirus particles, using this to develop broader-spectrum antivirals that inhibit enteroviruses from different groups, probably by interfering with viral RNA release.

Image credit: pbio.3000281

An Achilles' Heel for Rhino- and Enteroviruses

06/10/2019

Research Article

Better Primate Models for HIV-1?

The current animal model for HIV, the macaque, encodes a CD4 receptor that is non-permissive for HIV entry. Cody Warren, Sara Sawyer and co-authors reveal that six primate species encode CD4 receptors compatible with HIV infection, potentially making them powerful tools for the study of HIV biology. Furthermore, weak CD4 binding is a nearly constant, and apparently selected, property of HIV circulating in the human bloodstream.

Image credit: Flickr NIAID

Better Primate Models for HIV-1?

06/10/2019

Research Article

Phosphorylation and Placental Malaria

Placental sequestration of malaria-infected erythrocytes is mediated by the interaction between parasite VAR2CSA and the placental receptor chondroitin sulfate A; Dominique Dorin-Semblat, Benoît Gamain and co-workers show that phosphorylation of VAR2CSA plays a major role in this process, with implications for protecting pregnant women and their babies against placental malaria.

Phosphorylation and Placental Malaria

Image credit: Pixabay

06/11/2019

Research Article

ADAMTS13, Vasculature and Alzheimer's

Blood-brain barrier breakdown and cerebrovascular dysfunction contribute to the pathology and cognitive deficits of Alzheimer’s disease. Yongliang Cao, Haochen Xu, Yuanbo Zhu, Kai Zhong, Bing-Qiao Zhao, Wenying Fan and colleagues show that ADAMTS13 is an important regulator of cerebrovascular integrity, and can play a role in mitigating Alzheimer-like vascular dysfunction, vascular amyloid pathology and cognitive decline.

ADAMTS13, Vasculature and Alzheimer's

Image credit: pbio.3000313

06/13/2019

Research Article

T Cell Responses at the Receptor Level

Hypervariable T-cell receptors (TCRs) recognise a vast diversity of pathogen-derived antigens; Mikhail Pogorelyy, Anastasia Minervina, Thierry Mora, Aleksandra Walczak and co-workers show that TCRs responding to ongoing immune challenges can be identified using a statistical null model based on sequence similarity.

T Cell Responses at the Receptor Level

Image credit: pbio.3000314

06/13/2019

Research Article

Locked Antibodies Target Rheumatoid Arthritis

The incorporation of an IgG1 hinge as an antibody lock generates a pro-Infliximab whose activation is specific to the disease region, enabling safer RA therapy.

Locked Antibodies Target Rheumatoid Arthritis

Image credit: pbio.3000286

06/10/2019

Research Article

The Mechanism of Silver

The antimicrobial properties of silver are poorly understood. Tracking the silver(I) proteome in E. coli, in combination with metabolomics, bioinformatics and bioassays, delineates the dynamic antimicrobial actions of silver at a molecular level.

The Mechanism of Silver

Image credit: pbio.3000292

06/10/2019

Research Article

Anti-Apoptotic Role for Pyruvate Kinase

Pyruvate kinase M2, a major glycolytic enzyme thought to play a role in cancer progression, can actively inhibit apoptotic cell death by upregulating Mitofusin-1, a protein involved in the fusion of mitochondria.

Anti-Apoptotic Role for Pyruvate Kinase

Image credit: pbio.2004413

06/12/2019

Research Article

Nucleic Acids and Aggregation

FUS is an RNA-binding protein that is mutated and/or aggregated in several neurodegenerative diseases; this study shows that both ATP and nucleic acids modulate liquid-liquid phase separation of FUS in the same manner by specific binding.


Nucleic Acids and Aggregation

Image credit: pbio.3000327

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