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Photoreceptors’ essential inner scaffold

June 16, 2022

Photoreceptors’ essential inner scaffold

Olivier Mercey, Paul Guichard, Virginie Hamel and colleagues use ultrastructure expansion microscopy on mouse retina to reveal the presence of a novel structure inside the photoreceptor connecting cilium that protects the outer segment against degeneration. See also the related Primer.


Image credit: Olivier Mercey

PLOS Biologue

Community blog for PLOS Biology, PLOS Genetics and PLOS Computational Biology.

PLOS BIOLOGUE

06/17/2022

Primer

A structural zipper defective in blindness

Siebren Faber and Ronald Roepman explore a PLOS Biology study which uses ultrastructure expansion microscopy to study the inner scaffold of the photoreceptor connecting cilium, the location of multiple proteins implicated in inherited forms of progressive sight loss such as retinitis pigmentosa and Leber congenital amaurosis.

Image credit: pbio.3001672

A structural zipper defective in blindness

Recently Published Articles

06/16/2022

Perspective

The importance of tropical research

Tropical biology is currently largely absent from undergraduate curricula. Ann Russell and co-authors argue that the integration of authentic research in tropical biology could promote internationality among scientists and provide experiential learning that enables students to address complex global problems.

Image credit: J. Leighton Reid

The importance of tropical research

06/14/2022

Research Article

Gamma oscillations and stimulus discontinuities

Gamma oscillations in visual cortex have been proposed to play an important role in feature binding, but this role has recently been questioned. Vinay Shirhatti, Poojya Ravishankar and Supratim Ray show that visual stimulus-induced gamma oscillations are highly attenuated with even small discontinuities in the stimulus. This "resonant" behaviour can be explained by an excitatory-inhibitory model in which discontinuities lead to a reduction in lateral inputs.

Image credit: pbio.3001666

Gamma oscillations and stimulus discontinuities

06/14/2022

Research Article

How does valproic acid cause birth defects?

Does cellular senescence contribute to developmental birth defects? Muriel Rhinn, William Keyes and colleagues show that valproic acid induces cellular senescence in neuroepithelial cells, the precursors of all adult brain cells, and blocks their differentiation, suggesting that aberrant senescence in the embryo may contribute to postnatal cognitive defects.

How does valproic acid cause birth defects?

Image credit: pbio.3001664

06/13/2022

Short Reports

Single neuron type determines attraction versus aversion

Munzareen Khan, Piali Sengupta and co-workers examine how context modulates the valence of individual odorants in Caenorhabditis elegans, revealing that context-dependent engagement of distinct intracellular signaling pathways within a single sensory neuron type is sufficient to switch olfactory preference behavior to an individual odorant from attraction to aversion.

Single neuron type determines attraction versus aversion

Image credit: pbio.3001677

06/10/2022

Research Article

The polyol pathway senses glucose uptake

The polyol pathway, which converts glucose to fructose via sorbitol, was thought to be largely silent, and only the negative effects of its activation were known. Hiroko Sano, Masayasu Kojima and colleagues reveal that the polyol pathway is involved in glucose-responsive activation of Mondo/ChREBP-mediated metabolic remodeling in both mice and flies.

The polyol pathway senses glucose uptake

Image credit: Hiroko Sano

06/10/2022

Essay

Does brain activity cause consciousness?

Assuming technology advanced enough to fully manipulate our brains, this thought experiment addresses the question of whether action potentials cause consciousness.

Does brain activity cause consciousness?

Image credit: pbio.3001651

06/09/2022

Research Article

Mosquito siRNA pathways defend against pathogens

Overexpression of siRNA pathway factors in mosquitoes mediates a broad-spectrum antiviral action against human pathogenic viruses, also regulating responses against bacteria and fungi.

Mosquito siRNA pathways defend against pathogens

Image credit: pbio.3001668

06/09/2022

Discovery Report

Childhood obesity and the adult heart

Mendelian randomization provides evidence that being overweight during childhood may have a long-term influence on cardiac structure in later life.

Childhood obesity and the adult heart

Image credit: Wikimedia Commons user Ekko

06/07/2022

Research Article

All that is gold does not glitter

The most “beautiful” reef fish are tightly packed into small regions of both the phylogenetic tree and ecological trait space, and are less threatened than “ugly” fish.


All that is gold does not glitter

Image credit: pbio.3001640

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PLOS Biology | ISSN: 1545-7885 (online)