November 26, 2024
Image credit: Pixabay user jadorelyon
11/27/2024
Research Article
What causes an itchy skin in old age? Fang Tong, Shuai Liu, Chen Zhang, Xin Zhang, Qingjian Han and co-workers use aged mice to show that elevated release of vesicular Zn2+ from TMEM163-positive neurons dampens the activity of NPY neurons, thereby triggering the disinhibition of itch-transmitting neural circuits, in turn leading to chronic itch in aging.
Image credit: pbio.3002888
Current Issue October 2024
11/26/2024
Research Article
How do plant-associated microbiota regulate plant hormones, affecting their growth and development? Lanxiang Wang, Yue Liu, Haoran Ni, Moxian Chen, Lei Dai and co-authors reveal that bacterial isolates associated with the roots of Arabidopsis and rice can degrade the auxin indole-3-acetic acid (IAA), mitigating the inhibition of root growth induced by IAA-producing bacterial communities.
Image credit: pbio.3002921
11/26/2024
Research Article
What are the relative contributions of intraflagellar transport (IFT) and ciliary structure to sensory neuron responses? Alison Philbrook, Piali Sengupta and colleagues reveal unexpected complexity in the contribution of IFT and cilia organization to C. elegans chemosensory neuron responses and the precise modulation of olfactory behavior. Don't miss the accompanying Primer by Renny Ng and Chih-Ying Su.
Image credit: pbio.3002892
11/26/2024
Research Article
Protein-based therapies have been developed to block cytokine signaling in a range of different diseases. Timo Ullrich, Mohammad ElGamacy and co-authors use a computational protein design approach to develop novel cytokine receptor antagonists, and show that the designed proteins can inhibit G-CSFR activation in a cellular model of acute myeloid leukemia.
Image credit: pbio.3002883
11/25/2024
Methods and Resources
Traditional fluorescent proteins are commonly used to analyze biofilm dynamics, but their fluorescence signal diminishes during biofilm growth due to oxygen limitation. Jojo Prentice, Andrew Bridges and co-workers develop a novel fluorogenic cell-labeling approach using far-red probes to overcome these challenges, enabling long-term imaging and the study of biofilm dispersal.
Image credit: pbio.3002928
11/22/2024
Research Article
Triple-negative breast cancer (TBNC) is the most aggressive subtype, characterized by the infiltration of immune cells expressing high levels of CD74 to the tumor microenvironment. Bianca Pellegrino, Idit Shachar and co-workers show that CD74 enhances TBNC growth in mice by inhibiting anti-tumor immunity.
Image credit: pbio.3002905
11/26/2024
Perspective
The rise of antibiotic resistance calls for innovative solutions. This Perspective outlines how biology can be mined digitally using artificial intelligence as a new paradigm for antibiotic discovery, offering hope in the fight against superbugs.
Image credit: pbio.3002946
11/25/2024
Consensus View
Understanding the origin of eukaryotic cells is one of the most difficult problems in all of biology. This Consensus View lays out guidelines to identify the gene repertoire of the Last Eukaryotic Common Ancestor (LECA).
Image credit: pbio.3002917
11/22/2024
Perspective
This Perspective, written by members of the United2Act Research Working Group, proposes five key research questions on paper mills that require resourcing and support.
Image credit: Johann Bernhard Basedow via Wikimedia Commons
11/22/2024
Perspective
Queer and trans scientists face varied and systemic barriers to their professional success. This Perspective calls for a change in faculty hiring practices and presents concrete guidance to make it a more inclusive process.
Image credit: pbio.3002919
Neurotechnology offers unprecedented opportunities to treat neural disorders, restore brain function and enhance cognitive abilities. This collection explores the present and possible futures of neurotechnology to improve human health and cognition.
Translating conservation and biodiversity research from the field into the real world is a complex problem. This collection discusses issues around economics, policy, and how to do research that answers questions that decision makers have.
Symbiosis research has become a holistic and pervasive field with a mature theoretical basis. This collection showcases symbiotic relationships across the tree of life, exploring their evolutionary basis and underlying mechanisms.
PLOS Biology is 20 and we are celebrating with a collection that contains articles that look back at landmark studies that we published, others that look past and future, and others discussing how publishing and open science have evolved and what is to come.
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This collection explores engineering strategies to help us adapt plants to a changing climate, including breeding techniques, genome engineering, synthetic biology and microbiome engineering.
December 10 - 13
Meet Senior Editor Roli Roberts (rroberts@plos.org)
December 14 - 18
Meet Senior Editor Ines Alvarez-Garcia (ialvarez-garcia@plos.org)
February 27 - March 1
Meet Associate Editor Melissa Vazquez Hernandez (mvazquezhernandez@plos.org)
March 12 - 14
Meet Editor in Chief Nonia Pariente (npariente@plos.org)
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