Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Sandrine Belouzard; Arnaud Machelart; Valentin Sencio; Thibaut Vausselin; Eik Hoffmann; Nathalie Deboosere; Yves Rouillé; Lowiese Desmarets; Karin Séron; Adeline Danneels; Cyril Robil; Loic Belloy; Camille Moreau; Catherine Piveteau; Alexandre Biela; Alexandre Vandeputte; Séverine Heumel; Lucie Deruyter; Julie Dumont; Florence Leroux; Ilka Engelmann; Enagnon Kazali Alidjinou; Didier Hober; Priscille Brodin; Terence Beghyn; François Trottein; Benoit Deprez; Jean Dubuisson

doi:10.1371/journal.ppat.1010498

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Open Access

Peer-reviewed

Research Article

Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Sandrine Belouzard ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Arnaud Machelart ,

Roles Conceptualization, Formal analysis, Investigation

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Valentin Sencio ,

Contributed equally to this work with: Valentin Sencio, Thibaut Vausselin

Roles Conceptualization, Formal analysis, Investigation

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Thibaut Vausselin ,

Contributed equally to this work with: Valentin Sencio, Thibaut Vausselin

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology

Affiliations Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France, APTEEUS, Campus Pasteur Lille, Lille, France
⨯
Eik Hoffmann,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Nathalie Deboosere,

Roles Formal analysis, Investigation, Methodology

Affiliations Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France, Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France
⨯
Yves Rouillé,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Lowiese Desmarets,

Roles Formal analysis, Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Karin Séron,

Roles Formal analysis, Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Adeline Danneels,

Roles Formal analysis, Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Cyril Robil,

Roles Investigation

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Loic Belloy,

Roles Formal analysis, Investigation, Methodology

Affiliation APTEEUS, Campus Pasteur Lille, Lille, France
⨯
Camille Moreau,

Roles Formal analysis, Investigation, Methodology

Affiliation APTEEUS, Campus Pasteur Lille, Lille, France
⨯
Catherine Piveteau,

Roles Investigation, Methodology

Affiliation Univ Lille, Inserm, Institut Pasteur de Lille, Drugs and Molecules for Living Systems, Lille, France
⨯
Alexandre Biela,

Roles Investigation, Methodology

Affiliation Univ Lille, Inserm, Institut Pasteur de Lille, Drugs and Molecules for Living Systems, Lille, France
⨯
Alexandre Vandeputte,

Roles Data curation, Formal analysis, Methodology

Affiliations Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France, Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France
⨯
Séverine Heumel,

Roles Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Lucie Deruyter,

Roles Investigation, Methodology

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Julie Dumont,

Roles Formal analysis, Investigation, Methodology

Affiliations Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France, Univ Lille, Inserm, Institut Pasteur de Lille, Drugs and Molecules for Living Systems, Lille, France
⨯
Florence Leroux,

Roles Formal analysis, Methodology, Supervision

Affiliations Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France, Univ Lille, Inserm, Institut Pasteur de Lille, Drugs and Molecules for Living Systems, Lille, France
⨯
Ilka Engelmann,

Roles Investigation, Resources

Affiliation Univ Lille, CHU Lille, Laboratoire de Virologie, Lille, France
⨯
Enagnon Kazali Alidjinou,

Roles Investigation, Resources

Affiliation Univ Lille, CHU Lille, Laboratoire de Virologie, Lille, France
⨯
Didier Hober,

Roles Resources, Supervision

Affiliation Univ Lille, CHU Lille, Laboratoire de Virologie, Lille, France
⨯
Priscille Brodin ,

Roles Conceptualization, Methodology, Supervision, Validation

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliations Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France, Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France
⨯
Terence Beghyn ,

Roles Conceptualization, Methodology, Supervision, Validation

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliation APTEEUS, Campus Pasteur Lille, Lille, France
⨯
François Trottein ,

Roles Conceptualization, Formal analysis, Supervision, Validation, Writing – original draft

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France
⨯
Benoit Deprez ,

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft

* E-mail: benoit.deprez@univ-lille.fr (BD); jean.dubuisson@ibl.cnrs.fr (JD)

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliations Univ. Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, Plateformes lilloises en biologie et santé, Lille, France, Univ Lille, Inserm, Institut Pasteur de Lille, Drugs and Molecules for Living Systems, Lille, France
⨯
[ ... ],
Jean Dubuisson

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: benoit.deprez@univ-lille.fr (BD); jean.dubuisson@ibl.cnrs.fr (JD)

¶‡ SB and AM are equally contributing first authors. PB, TB, FT, BD and JD are equally contributing senior authors.

Affiliation Univ Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Center for Infection and Immunity of Lille, Lille, France

https://orcid.org/0000-0003-1626-7693

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Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice

Sandrine Belouzard,
Arnaud Machelart,
Valentin Sencio,
Thibaut Vausselin,
Eik Hoffmann,
Nathalie Deboosere,
Yves Rouillé,
Lowiese Desmarets,
Karin Séron,
Adeline Danneels

Published: May 19, 2022
https://doi.org/10.1371/journal.ppat.1010498

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