June 2015

E18 mouse hippocampal neurons at day in vitro 15 (DIV15) are stained with anti-CAR (coxsackievirus adenovirus receptor) antibodies. The extracellular domain of CAR is labeled with RmcB and an anti-mouse (Alexa-488 green) and the intracellular tail of CAR is labeled with a rabbit polyclonal antibody with the secondary anti-rabbit (Alexa-647, red). Kremer et al.

Image Credit: Eric J. Kremer

Editorial

Introducing “Research Matters”

Grant McFadden, Kasturi Haldar

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1005014

Pearls

Exploring Host–Pathogen Interactions through Biological Control

Francesca Di Giallonardo, Edward C. Holmes

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1004865

Host Delivery of Favorite Meals for Intracellular Pathogens

Yousef Abu Kwaik, Dirk Bumann

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1004866

Waterborne Viruses: A Barrier to Safe Drinking Water

Aimee M. Gall, Benito J. Mariñas, Yi Lu, Joanna L. Shisler

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1004867

Is Development of a Vaccine against Cryptococcus neoformans Feasible?

Chrissy M. Leopold Wager, Floyd L. Wormley Jr.

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004843

Successes and Challenges on the Road to Cure Hepatitis C

Stacy M. Horner, Susanna Naggie

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004854

Analysis of Bottlenecks in Experimental Models of Infection

Sören Abel, Pia Abel zur Wiesch, Brigid M. Davis, Matthew K. Waldor

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004823

Archaea in and on the Human Body: Health Implications and Future Directions

Mor N. Lurie-Weinberger, Uri Gophna

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004833

Battling Phages: How Bacteria Defend against Viral Attack

Kimberley D. Seed

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004847

Expected and Unexpected Features of the Newly Discovered Bat Influenza A-like Viruses

Wenjun Ma, Adolfo García-Sastre, Martin Schwemmle

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004819

Adenovirus Tales: From the Cell Surface to the Nuclear Pore Complex

Eric J. Kremer, Glen R. Nemerow

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004821

A 21st Century Perspective of Poliovirus Replication

Nicolas Lévêque, Bert L. Semler

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004825

Review

Targeting Human Transmission Biology for Malaria Elimination

Sandra K. Nilsson, Lauren M. Childs, Caroline Buckee, Matthias Marti

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004871

Research Matters

The Curious Road from Basic Pathogen Research to Clinical Translation

Grant McFadden

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1004997

From Cell and Organismal Biology to Drugs

Kasturi Haldar

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1005002

Research Articles

A Structural and Functional Comparison Between Infectious and Non-Infectious Autocatalytic Recombinant PrP Conformers

Geoffrey P. Noble, Daphne W. Wang, Daniel J. Walsh, Justin R. Barone, Michael B. Miller, Koren A. Nishina, Sheng Li, Surachai Supattapone

PLOS Pathogens: published June 30, 2015 | https://doi.org/10.1371/journal.ppat.1005017

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells

Wilfried Posch, Marion Steger, Ulla Knackmuss, Michael Blatzer, Hanna-Mari Baldauf, Wolfgang Doppler, Tommy E. White, Paul Hörtnagl, Felipe Diaz-Griffero, Cornelia Lass-Flörl, Hubert Hackl, Arnaud Moris, Oliver T. Keppler, Doris Wilflingseder

PLOS Pathogens: published June 29, 2015 | https://doi.org/10.1371/journal.ppat.1005005

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta, Sujoy Dutta, Mohanan Valiya Veettil, Arunava Roy, Mairaj Ahmed Ansari, Jawed Iqbal, Leela Chikoti, Binod Kumar, Karen E. Johnson, Bala Chandran

PLOS Pathogens: published June 29, 2015 | https://doi.org/10.1371/journal.ppat.1005030

Fungal Morphology, Iron Homeostasis, and Lipid Metabolism Regulated by a GATA Transcription Factor in Blastomyces dermatitidis

Amber J. Marty, Aimee T. Broman, Robert Zarnowski, Teigan G. Dwyer, Laura M. Bond, Anissa Lounes-Hadj Sahraoui, Joël Fontaine, James M. Ntambi, Sündüz Keleş, Christina Kendziorski, Gregory M. Gauthier

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1004959

Peptidoglycan Branched Stem Peptides Contribute to Streptococcus pneumoniae Virulence by Inhibiting Pneumolysin Release

Neil G. Greene, Ana R. Narciso, Sergio R. Filipe, Andrew Camilli

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1004996

Sequence-Specific Fidelity Alterations Associated with West Nile Virus Attenuation in Mosquitoes

Greta A. Van Slyke, Jamie J. Arnold, Alex J. Lugo, Sara B. Griesemer, Ibrahim M. Moustafa, Laura D. Kramer, Craig E. Cameron, Alexander T. Ciota

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1005009

Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria

Karen J. Kieser, Cara C. Boutte, Jemila C. Kester, Christina E. Baer, Amy K. Barczak, Xavier Meniche, Michael C. Chao, E. Hesper Rego, Christopher M. Sassetti, Sarah M. Fortune, Eric J. Rubin

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1005010

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

Yanming Wang, Qiaoshi Lian, Bo Yang, Shanshan Yan, Haiyan Zhou, Lan He, Guomei Lin, Zhexiong Lian, Zhengfan Jiang, Bing Sun

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1005012

Protective mAbs and Cross-Reactive mAbs Raised by Immunization with Engineered Marburg Virus GPs

Marnie L. Fusco, Takao Hashiguchi, Robyn Cassan, Julia E. Biggins, Charles D. Murin, Kelly L. Warfield, Sheng Li, Frederick W. Holtsberg, Sergey Shulenin, Hong Vu, Gene G. Olinger, Do H. Kim, Kevin J. Whaley, Larry Zeitlin, Andrew B. Ward, Cory Nykiforuk, M. Javad Aman, Jody Berry, Erica Ollmann Saphire

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1005016

Human Immunodeficiency Virus Type 1 Nef Inhibits Autophagy through Transcription Factor EB Sequestration

Grant R. Campbell, Pratima Rawat, Rachel S. Bruckman, Stephen A. Spector

PLOS Pathogens: published June 26, 2015 | https://doi.org/10.1371/journal.ppat.1005018

Specific Cell Targeting Therapy Bypasses Drug Resistance Mechanisms in African Trypanosomiasis

Juan D. Unciti-Broceta, José L. Arias, José Maceira, Miguel Soriano, Matilde Ortiz-González, José Hernández-Quero, Manuel Muñóz-Torres, Harry P. de Koning, Stefan Magez, José A. Garcia-Salcedo

PLOS Pathogens: published June 25, 2015 | https://doi.org/10.1371/journal.ppat.1004942

Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation

Janet J. Sei, Scott Haskett, Lauren W. Kaminsky, Eugene Lin, Mary E. Truckenmiller, Clifford J. Bellone, R. Mark Buller, Christopher C. Norbury

PLOS Pathogens: published June 24, 2015 | https://doi.org/10.1371/journal.ppat.1004941

HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures

Adam Pickard, Simon S. McDade, Marie McFarland, W. Glenn McCluggage, Cosette M. Wheeler, Dennis J. McCance

PLOS Pathogens: published June 24, 2015 | https://doi.org/10.1371/journal.ppat.1004988

Inter-Seasonal Influenza is Characterized by Extended Virus Transmission and Persistence

Zoe Patterson Ross, Naomi Komadina, Yi-Mo Deng, Natalie Spirason, Heath A. Kelly, Sheena G. Sullivan, Ian G. Barr, Edward C. Holmes

PLOS Pathogens: published June 24, 2015 | https://doi.org/10.1371/journal.ppat.1004991

Recombinant Murine Gamma Herpesvirus 68 Carrying KSHV G Protein-Coupled Receptor Induces Angiogenic Lesions in Mice

Junjie Zhang, Lining Zhu, Xiaolu Lu, Emily R. Feldman, Lisa R. Keyes, Yi Wang, Hui Fan, Hao Feng, Zanxian Xia, Jiya Sun, Taijiao Jiang, Shou-jiang Gao, Scott A. Tibbetts, Pinghui Feng

PLOS Pathogens: published June 24, 2015 | https://doi.org/10.1371/journal.ppat.1005001

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking

Steven J. Siegel, Edwin Tamashiro, Jeffrey N. Weiser

PLOS Pathogens: published June 24, 2015 | https://doi.org/10.1371/journal.ppat.1005004

Twilight, a Novel Circadian-Regulated Gene, Integrates Phototropism with Nutrient and Redox Homeostasis during Fungal Development

Yi Zhen Deng, Ziwei Qu, Naweed I. Naqvi

PLOS Pathogens: published June 23, 2015 | https://doi.org/10.1371/journal.ppat.1004972

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Jerome Deval, Jin Hong, Guangyi Wang, Josh Taylor, Lucas K. Smith, Amy Fung, Sarah K. Stevens, Hong Liu, Zhinan Jin, Natalia Dyatkina, Marija Prhavc, Antitsa D. Stoycheva, Vladimir Serebryany, Jyanwei Liu, David B. Smith, Yuen Tam, Qingling Zhang, Martin L. Moore, Rachel Fearns, Sushmita M. Chanda, Lawrence M. Blatt, Julian A. Symons, Leo Beigelman

PLOS Pathogens: published June 22, 2015 | https://doi.org/10.1371/journal.ppat.1004995

The Role of ExoS in Dissemination of Pseudomonas aeruginosa during Pneumonia

Stephanie M. Rangel, Maureen H. Diaz, Claire A. Knoten, Angelica Zhang, Alan R. Hauser

PLOS Pathogens: published June 19, 2015 | https://doi.org/10.1371/journal.ppat.1004945

Neuronal Subtype and Satellite Cell Tropism Are Determinants of Varicella-Zoster Virus Virulence in Human Dorsal Root Ganglia Xenografts In Vivo

Leigh Zerboni, Ann Arvin

PLOS Pathogens: published June 19, 2015 | https://doi.org/10.1371/journal.ppat.1004989

The Role of Human Transportation Networks in Mediating the Genetic Structure of Seasonal Influenza in the United States

Brooke A. Bozick, Leslie A. Real

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004898

Single-Cell and Single-Cycle Analysis of HIV-1 Replication

Mowgli Holmes, Fengwen Zhang, Paul D. Bieniasz

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004961

Degradation of Human PDZ-Proteins by Human Alphapapillomaviruses Represents an Evolutionary Adaptation to a Novel Cellular Niche

Koenraad Van Doorslaer, Rob DeSalle, Mark H. Einstein, Robert D. Burk

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004980

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains

Christina D. Orrú, Bradley R. Groveman, Lynne D. Raymond, Andrew G. Hughson, Romolo Nonno, Wenquan Zou, Bernardino Ghetti, Pierluigi Gambetti, Byron Caughey

PLOS Pathogens: published June 18, 2015 | https://doi.org/10.1371/journal.ppat.1004983

Two Cdc2 Kinase Genes with Distinct Functions in Vegetative and Infectious Hyphae in Fusarium graminearum

Huiquan Liu, Shijie Zhang, Jiwen Ma, Yafeng Dai, Chaohui Li, Xueliang Lyu, Chenfang Wang, Jin-Rong Xu

PLOS Pathogens: published June 17, 2015 | https://doi.org/10.1371/journal.ppat.1004913

Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells

Emily F. A. van ‘t Wout, Annemarie van Schadewijk, Ria van Boxtel, Lucy E. Dalton, Hanna J. Clarke, Jan Tommassen, Stefan J. Marciniak, Pieter S. Hiemstra

PLOS Pathogens: published June 17, 2015 | https://doi.org/10.1371/journal.ppat.1004946

The Herpes Simplex Virus Protein pUL31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain

Christina Funk, Melanie Ott, Verena Raschbichler, Claus-Henning Nagel, Anne Binz, Beate Sodeik, Rudolf Bauerfeind, Susanne M. Bailer

PLOS Pathogens: published June 17, 2015 | https://doi.org/10.1371/journal.ppat.1004957

RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo

Catherine Ptaschinski, Sumanta Mukherjee, Martin L. Moore, Mareike Albert, Kristian Helin, Steven L. Kunkel, Nicholas W. Lukacs

PLOS Pathogens: published June 17, 2015 | https://doi.org/10.1371/journal.ppat.1004978

The νSaα Specific Lipoprotein Like Cluster (lpl) of S. aureus USA300 Contributes to Immune Stimulation and Invasion in Human Cells

Minh Thu Nguyen, Beatrice Kraft, Wenqi Yu, Dogan Doruk Demicrioglu, Tobias Hertlein, Marc Burian, Mathias Schmaler, Klaus Boller, Isabelle Bekeredjian-Ding, Knut Ohlsen, Birgit Schittek, Friedrich Götz

PLOS Pathogens: published June 17, 2015 | https://doi.org/10.1371/journal.ppat.1004984

A Macrophage Subversion Factor Is Shared by Intracellular and Extracellular Pathogens

Claudine Belon, Chantal Soscia, Audrey Bernut, Aurélie Laubier, Sophie Bleves, Anne-Béatrice Blanc-Potard

PLOS Pathogens: published June 16, 2015 | https://doi.org/10.1371/journal.ppat.1004969

Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection

Emily Adland, Paolo Paioni, Christina Thobakgale, Leana Laker, Luisa Mori, Maximilian Muenchhoff, Anna Csala, Margaret Clapson, Jacquie Flynn, Vas Novelli, Jacob Hurst, Vanessa Naidoo, Roger Shapiro, Kuan-Hsiang Gary Huang, John Frater, Andrew Prendergast, Julia G. Prado, Thumbi Ndung’u, Bruce D. Walker, Mary Carrington, Pieter Jooste, Philip J. R. Goulder

PLOS Pathogens: published June 15, 2015 | https://doi.org/10.1371/journal.ppat.1004954

Host Transcriptional Response to Influenza and Other Acute Respiratory Viral Infections – A Prospective Cohort Study

Yijie Zhai, Luis M. Franco, Robert L. Atmar, John M. Quarles, Nancy Arden, Kristine L. Bucasas, Janet M. Wells, Diane Niño, Xueqing Wang, Gladys E. Zapata, Chad A. Shaw, John W. Belmont, Robert B. Couch

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004869

Surface-Associated Lipoproteins Link Enterococcus faecalis Virulence to Colitogenic Activity in IL-10-Deficient Mice Independent of Their Expression Levels

Soeren Ocvirk, Irina G. Sava, Isabella Lengfelder, Ilias Lagkouvardos, Natalie Steck, Jung H. Roh, Sandrine Tchaptchet, Yinyin Bao, Jonathan J. Hansen, Johannes Huebner, Ian M. Carroll, Barbara E. Murray, R. Balfour Sartor, Dirk Haller

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004911

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

Jennifer Cnops, Carl De Trez, Benoit Stijlemans, Jiri Keirsse, Florence Kauffmann, Mark Barkhuizen, Roanne Keeton, Louis Boon, Frank Brombacher, Stefan Magez

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004964

Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome

Xi Luo, David J. Wasilko, Yao Liu, Jiayi Sun, Xiaochun Wu, Zhao-Qing Luo, Yuxin Mao

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004965

Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular

Jason H. Melehani, David B. A. James, Ashley L. DuMont, Victor J. Torres, Joseph A. Duncan

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004970

EBV BART MicroRNAs Target Multiple Pro-apoptotic Cellular Genes to Promote Epithelial Cell Survival

Dong Kang, Rebecca L. Skalsky, Bryan R. Cullen

PLOS Pathogens: published June 12, 2015 | https://doi.org/10.1371/journal.ppat.1004979

Latent Membrane Protein LMP2A Impairs Recognition of EBV-Infected Cells by CD8+ T Cells

Chiara Rancan, Leah Schirrmann, Corinna Hüls, Reinhard Zeidler, Andreas Moosmann

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004906

The Mammalian Cell Cycle Regulates Parvovirus Nuclear Capsid Assembly

Jon Gil-Ranedo, Eva Hernando, Laura Riolobos, Carlos Domínguez, Michael Kann, José M. Almendral

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004920

Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers

Enrique Martin-Gayo, Maria Jose Buzon, Zhengyu Ouyang, Taylor Hickman, Jacqueline Cronin, Dina Pimenova, Bruce D. Walker, Mathias Lichterfeld, Xu G. Yu

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004930

HIV Latency Is Established Directly and Early in Both Resting and Activated Primary CD4 T Cells

Leonard Chavez, Vincenzo Calvanese, Eric Verdin

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004955

A Novel AT-Rich DNA Recognition Mechanism for Bacterial Xenogeneic Silencer MvaT

Pengfei Ding, Kirsty A. McFarland, Shujuan Jin, Grace Tong, Bo Duan, Ally Yang, Timothy R. Hughes, Jun Liu, Simon L. Dove, William Wiley Navarre, Bin Xia

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004967

Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease

Timothy M. Hill, Pavlo Gilchuk, Basak B. Cicek, Maria A. Osina, Kelli L. Boyd, Douglas M. Durrant, Dennis W. Metzger, Kamal M. Khanna, Sebastian Joyce

PLOS Pathogens: published June 11, 2015 | https://doi.org/10.1371/journal.ppat.1004975

Reovirus FAST Proteins Drive Pore Formation and Syncytiogenesis Using a Novel Helix-Loop-Helix Fusion-Inducing Lipid Packing Sensor

Jolene Read, Eileen K. Clancy, Muzaddid Sarker, Roberto de Antueno, David N. Langelaan, Hiren B. Parmar, Kyungsoo Shin, Jan K. Rainey, Roy Duncan

PLOS Pathogens: published June 10, 2015 | https://doi.org/10.1371/journal.ppat.1004962

A Critical Role for CLSP2 in the Modulation of Antifungal Immune Response in Mosquitoes

Yan-Hong Wang, Yang Hu, Long-Sheng Xing, Hong Jiang, Song-Nian Hu, Alexander S. Raikhel, Zhen Zou

PLOS Pathogens: published June 9, 2015 | https://doi.org/10.1371/journal.ppat.1004931

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

Bishi Fu, Lingyan Wang, Hao Ding, Jens C. Schwamborn, Shitao Li, Martin E. Dorf

PLOS Pathogens: published June 9, 2015 | https://doi.org/10.1371/journal.ppat.1004960

An Ultrasensitive Mechanism Regulates Influenza Virus-Induced Inflammation

Jason E. Shoemaker, Satoshi Fukuyama, Amie J. Eisfeld, Dongming Zhao, Eiryo Kawakami, Saori Sakabe, Tadashi Maemura, Takeo Gorai, Hiroaki Katsura, Yukiko Muramoto, Shinji Watanabe, Tokiko Watanabe, Ken Fuji, Yukiko Matsuoka, Hiroaki Kitano, Yoshihiro Kawaoka

PLOS Pathogens: published June 5, 2015 | https://doi.org/10.1371/journal.ppat.1004856

IRF-5-Mediated Inflammation Limits CD8⁺ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection

Akil Hammami, Tania Charpentier, Mélina Smans, Simona Stäger

PLOS Pathogens: published June 5, 2015 | https://doi.org/10.1371/journal.ppat.1004938

Crystal Structure of USP7 Ubiquitin-like Domains with an ICP0 Peptide Reveals a Novel Mechanism Used by Viral and Cellular Proteins to Target USP7

Roland Pfoh, Ira Kay Lacdao, Anna A. Georges, Adam Capar, Hong Zheng, Lori Frappier, Vivian Saridakis

PLOS Pathogens: published June 5, 2015 | https://doi.org/10.1371/journal.ppat.1004950

Activated Brain Endothelial Cells Cross-Present Malaria Antigen

Shanshan W. Howland, Chek Meng Poh, Laurent Rénia

PLOS Pathogens: published June 5, 2015 | https://doi.org/10.1371/journal.ppat.1004963

Host Reticulocytes Provide Metabolic Reservoirs That Can Be Exploited by Malaria Parasites

Anubhav Srivastava, Darren J. Creek, Krystal J. Evans, David De Souza, Louis Schofield, Sylke Müller, Michael P. Barrett, Malcolm J. McConville, Andrew P. Waters

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004882

The Proteome of the Isolated Chlamydia trachomatis Containing Vacuole Reveals a Complex Trafficking Platform Enriched for Retromer Components

Lukas Aeberhard, Sebastian Banhart, Martina Fischer, Nico Jehmlich, Laura Rose, Sophia Koch, Michael Laue, Bernhard Y. Renard, Frank Schmidt, Dagmar Heuer

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004883

An In Vitro Model of Latency and Reactivation of Varicella Zoster Virus in Human Stem Cell-Derived Neurons

Amos Markus, Ilana Lebenthal-Loinger, In Hong Yang, Paul R. Kinchington, Ronald S. Goldstein

PLOS Pathogens: published June 4, 2015 | https://doi.org/10.1371/journal.ppat.1004885

Natural Variants of the KPC-2 Carbapenemase have Evolved Increased Catalytic Efficiency for Ceftazidime Hydrolysis at the Cost of Enzyme Stability

Shrenik C. Mehta, Kacie Rice, Timothy Palzkill

PLOS Pathogens: published June 1, 2015 | https://doi.org/10.1371/journal.ppat.1004949

Cover

CAR expression on neurons.

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