March 2013

Dengue virus (DENV) NS5 protein inhibits type I interferon signaling by mediating the proteasomal degradation of STAT2, which results in enhanced viral replication and dissemination in the host. Morrison et al. show that DENV NS5 protein interacts with UBR4, a member of a family of predicted E3 ligases. This interaction is critical for DENV NS5-mediated STAT2 degradation, and consequently for DENV replication, in the presence of a competent type I interferon system. This picture shows the co-localization of DENV NS5 with UBR4.

Image Credit: Giuseppe Pisanelli, Icahn School of Medicine at Mount Sinai, New York, NY, USA

Opinion

Redefining the Immune System as a Social Interface for Cooperative Processes

Eric Muraille

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003203

Pearls

Generators of Phenotypic Diversity in the Evolution of Pathogenic Microorganisms

Silvia Calo, R. Blake Billmyre, Joseph Heitman

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003181

Surviving the Heat of the Moment: A Fungal Pathogens Perspective

Michelle D. Leach, Leah E. Cowen

PLOS Pathogens: published March 7, 2013 | https://doi.org/10.1371/journal.ppat.1003163

Reviews

The KdpD/KdpE Two-Component System: Integrating K⁺ Homeostasis and Virulence

Zoë N. Freeman, Steve Dorus, Nicholas R. Waterfield

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003201

The Rapidly Expanding Family of Human Polyomaviruses: Recent Developments in Understanding Their Life Cycle and Role in Human Pathology

Martyn K. White, Jennifer Gordon, Kamel Khalili

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003206

Research Articles

HSV-2 Specifically Down Regulates HLA-C Expression to Render HSV-2-Infected DCs Susceptible to NK Cell Killing

Moran Elboim, Inna Grodzovski, Esther Djian, Dana G. Wolf, Ofer Mandelboim

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003226

Productive Homologous and Non-homologous Recombination of Hepatitis C Virus in Cell Culture

Troels K. H. Scheel, Andrea Galli, Yi-Ping Li, Lotte S. Mikkelsen, Judith M. Gottwein, Jens Bukh

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003228

TIM-family Proteins Promote Infection of Multiple Enveloped Viruses through Virion-associated Phosphatidylserine

Stephanie Jemielity, Jinyize J. Wang, Ying Kai Chan, Asim A. Ahmed, Wenhui Li, Sheena Monahan, Xia Bu, Michael Farzan, Gordon J. Freeman, Dale T. Umetsu, Rosemarie H. DeKruyff, Hyeryun Choe

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003232

Prophage Induction Is Enhanced and Required for Renal Disease and Lethality in an EHEC Mouse Model

Jessica S. Tyler, Karen Beeri, Jared L. Reynolds, Christopher J. Alteri, Katherine G. Skinner, Jonathan H. Friedman, Kathryn A. Eaton, David I. Friedman

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003236

Digoxin Suppresses HIV-1 Replication by Altering Viral RNA Processing

Raymond W. Wong, Ahalya Balachandran, Mario A. Ostrowski, Alan Cochrane

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003241

HIV Restriction by APOBEC3 in Humanized Mice

John F. Krisko, Francisco Martinez-Torres, John L. Foster, J. Victor Garcia

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003242

Two-Component Signal Transduction System CBO0787/CBO0786 Represses Transcription from Botulinum Neurotoxin Promoters in Clostridium botulinum ATCC 3502

Zhen Zhang, Hannu Korkeala, Elias Dahlsten, Elina Sahala, John T. Heap, Nigel P. Minton, Miia Lindström

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003252

Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII

Hong You, Donald P. McManus, Wei Hu, Michael J. Smout, Paul J. Brindley, Geoffrey N. Gobert

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003254

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Lucy Glover, Sam Alsford, David Horn

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003260

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

Juliet Morrison, Maudry Laurent-Rolle, Ana M. Maestre, Ricardo Rajsbaum, Giuseppe Pisanelli, Viviana Simon, Lubbertus C. F. Mulder, Ana Fernandez-Sesma, Adolfo García-Sastre

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003265

Hantavirus-infection Confers Resistance to Cytotoxic Lymphocyte-Mediated Apoptosis

Shawon Gupta, Monika Braun, Nicole D. Tischler, Malin Stoltz, Karin B. Sundström, Niklas K. Björkström, Hans-Gustaf Ljunggren, Jonas Klingström

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003272

A Ubiquitin-specific Protease Possesses a Decisive Role for Adenovirus Replication and Oncogene-mediated Transformation

Wilhelm Ching, Emre Koyuncu, Sonia Singh, Christina Arbelo-Roman, Barbara Hartl, Elisabeth Kremmer, Thomas Speiseder, Chris Meier, Thomas Dobner

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003273

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

Adam K. A. Wright, Mathieu Bangert, Jenna F. Gritzfeld, Daniela M. Ferreira, Kondwani C. Jambo, Angela D. Wright, Andrea M. Collins, Stephen B. Gordon

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003274

Monomeric Nucleoprotein of Influenza A Virus

Sylvie Chenavas, Leandro F. Estrozi, Anny Slama-Schwok, Bernard Delmas, Carmelo Di Primo, Florence Baudin, Xinping Li, Thibaut Crépin, Rob W. H. Ruigrok

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003275

Pandemic Influenza A Viruses Escape from Restriction by Human MxA through Adaptive Mutations in the Nucleoprotein

Benjamin Mänz, Dominik Dornfeld, Veronika Götz, Roland Zell, Petra Zimmermann, Otto Haller, Georg Kochs, Martin Schwemmle

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003279

Pseudomonas syringae pv. syringae Uses Proteasome Inhibitor Syringolin A to Colonize from Wound Infection Sites

Johana C. Misas-Villamil, Izabella Kolodziejek, Emerson Crabill, Farnusch Kaschani, Sherry Niessen, Takayuki Shindo, Markus Kaiser, James R. Alfano, Renier A. L. van der Hoorn

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003281

Hepatitis C Virus Induces the Mitochondrial Translocation of Parkin and Subsequent Mitophagy

Seong-Jun Kim, Gulam H. Syed, Aleem Siddiqui

PLOS Pathogens: published March 28, 2013 | https://doi.org/10.1371/journal.ppat.1003285

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

Claudine Porta, Abhay Kotecha, Alison Burman, Terry Jackson, Jingshan Ren, Silvia Loureiro, Ian M. Jones, Elizabeth E. Fry, David I. Stuart, Bryan Charleston

PLOS Pathogens: published March 27, 2013 | https://doi.org/10.1371/journal.ppat.1003255

Biomphalysin, a New β Pore-forming Toxin Involved in Biomphalaria glabrata Immune Defense against Schistosoma mansoni

Richard Galinier, Julien Portela, Yves Moné, Jean François Allienne, Hélène Henri, Stéphane Delbecq, Guillaume Mitta, Benjamin Gourbal, David Duval

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003216

Structure of Human Cytomegalovirus UL141 Binding to TRAIL-R2 Reveals Novel, Non-canonical Death Receptor Interactions

Ivana Nemčovičová, Chris A. Benedict, Dirk M. Zajonc

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003224

Plasminogen Controls Inflammation and Pathogenesis of Influenza Virus Infections via Fibrinolysis

Fatma Berri, Guus F. Rimmelzwaan, Michel Hanss, Emmanuel Albina, Marie-Laure Foucault-Grunenwald, Vuong B. Lê, Stella E. Vogelzang-van Trierum, Patrica Gil, Eric Camerer, Dominique Martinez, Bruno Lina, Roger Lijnen, Peter Carmeliet, Béatrice Riteau

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003229

Enterovirus 71 Protease 2A^pro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

Bei Wang, Xueyan Xi, Xiaobo Lei, Xiaoyan Zhang, Sheng Cui, Jianwei Wang, Qi Jin, Zhendong Zhao

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003231

Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis

Yannick Simonin, Serena Vegna, Leila Akkari, Damien Grégoire, Etienne Antoine, Jacques Piette, Nicolas Floc'h, Patrice Lassus, Guann-Yi Yu, Arielle R. Rosenberg, Michael Karin, David Durantel, Urszula Hibner

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003234

Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae

Amber M. Smith, Frederick R. Adler, Ruy M. Ribeiro, Ryan N. Gutenkunst, Julie L. McAuley, Jonathan A. McCullers, Alan S. Perelson

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003238

A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus

Jacquelyn Horsington, Helena Lynn, Lynne Turnbull, Delfine Cheng, Filip Braet, Russell J. Diefenbach, Cynthia B. Whitchurch, Guna Karupiah, Timothy P. Newsome

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003239

The Enterovirus 71 A-particle Forms a Gateway to Allow Genome Release: A CryoEM Study of Picornavirus Uncoating

Kristin L. Shingler, Jennifer L. Yoder, Michael S. Carnegie, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Susan Hafenstein

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003240

IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection

Claudia Gonzalez-Lombana, Ciara Gimblet, Olivia Bacellar, Walker W. Oliveira, Sara Passos, Lucas P. Carvalho, Michael Goldschmidt, Edgar M. Carvalho, Phillip Scott

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003243

Temporal Analysis of Hepatitis C Virus Cell Entry with Occludin Directed Blocking Antibodies

Marion Sourisseau, Maria L. Michta, Chati Zony, Benjamin Israelow, Sharon E. Hopcraft, Christopher M. Narbus, Ana Parra Martín, Matthew J. Evans

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003244

The Common Structural Architecture of Shigella flexneri and Salmonella typhimurium Type Three Secretion Needles

Jean-Philippe Demers, Nikolaos G. Sgourakis, Rashmi Gupta, Antoine Loquet, Karin Giller, Dietmar Riedel, Britta Laube, Michael Kolbe, David Baker, Stefan Becker, Adam Lange

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003245

Dimeric RNA Recognition Regulates HIV-1 Genome Packaging

Olga A. Nikolaitchik, Kari A. Dilley, William Fu, Robert J. Gorelick, S.-H. Sheldon Tai, Ferri Soheilian, Roger G. Ptak, Kunio Nagashima, Vinay K. Pathak, Wei-Shau Hu

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003249

TIM-3 Does Not Act as a Receptor for Galectin-9

Judith Leitner, Armin Rieger, Winfried F. Pickl, Gerhard Zlabinger, Katharina Grabmeier-Pfistershammer, Peter Steinberger

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003253

Dendritic Cell-induced Activation of Latent HIV-1 Provirus in Actively Proliferating Primary T Lymphocytes

Renée M. van der Sluis, Thijs van Montfort, Georgios Pollakis, Rogier W. Sanders, Dave Speijer, Ben Berkhout, Rienk E. Jeeninga

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003259

Genome-wide Determinants of Proviral Targeting, Clonal Abundance and Expression in Natural HTLV-1 Infection

Anat Melamed, Daniel J. Laydon, Nicolas A. Gillet, Yuetsu Tanaka, Graham P. Taylor, Charles R. M. Bangham

PLOS Pathogens: published March 21, 2013 | https://doi.org/10.1371/journal.ppat.1003271

Genome-wide Prediction and Functional Validation of Promoter Motifs Regulating Gene Expression in Spore and Infection Stages of Phytophthora infestans

Sourav Roy, Meenakshi Kagda, Howard S. Judelson

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003182

Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

Rosita Accardi, Ikbal Fathallah, Henri Gruffat, Giuseppe Mariggiò, Florence Le Calvez-Kelm, Catherine Voegele, Birke Bartosch, Hector Hernandez-Vargas, James McKay, Bakary S. Sylla, Evelyne Manet, Massimo Tommasino

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003186

Cooperativity Between CD8+ T Cells, Non-Neutralizing Antibodies, and Alveolar Macrophages Is Important for Heterosubtypic Influenza Virus Immunity

Brian J. Laidlaw, Vilma Decman, Mohammed-Alkhatim A. Ali, Michael C. Abt, Amaya I. Wolf, Laurel A. Monticelli, Krystyna Mozdzanowska, Jill M. Angelosanto, David Artis, Jan Erikson, E. John Wherry

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003207

The Third Signal Cytokine IL-12 Rescues the Anti-Viral Function of Exhausted HBV-Specific CD8 T Cells

Anna Schurich, Laura J. Pallett, Marcin Lubowiecki, Harsimran D. Singh, Upkar S. Gill, Patrick T. Kennedy, Eleni Nastouli, Sudeep Tanwar, William Rosenberg, Mala K. Maini

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003208

Evolution of Virulence in Emerging Epidemics

Thomas W. Berngruber, Rémy Froissart, Marc Choisy, Sylvain Gandon

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003209

Post-Treatment HIV-1 Controllers with a Long-Term Virological Remission after the Interruption of Early Initiated Antiretroviral Therapy ANRS VISCONTI Study

Asier Sáez-Cirión, Charline Bacchus, Laurent Hocqueloux, Véronique Avettand-Fenoel, Isabelle Girault, Camille Lecuroux, Valerie Potard, Pierre Versmisse, Adeline Melard, Thierry Prazuck, Benjamin Descours, Julien Guergnon, Jean-Paul Viard, Faroudy Boufassa, Olivier Lambotte, Cécile Goujard, Laurence Meyer, Dominique Costagliola, Alain Venet, Gianfranco Pancino, Brigitte Autran, Christine Rouzioux, the ANRS VISCONTI Study Group

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003211

Th2 Cell-Intrinsic Hypo-Responsiveness Determines Susceptibility to Helminth Infection

Nienke van der Werf, Stephen A. Redpath, Miyuki Azuma, Hideo Yagita, Matthew D. Taylor

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003215

Trichoderma-Plant Root Colonization: Escaping Early Plant Defense Responses and Activation of the Antioxidant Machinery for Saline Stress Tolerance

Yariv Brotman, Udi Landau, Álvaro Cuadros-Inostroza, Tohge Takayuki, Alisdair R. Fernie, Ilan Chet, Ada Viterbo, Lothar Willmitzer

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003221

Glycomic Analysis of Human Respiratory Tract Tissues and Correlation with Influenza Virus Infection

Trevenan Walther, Rositsa Karamanska, Renee W. Y. Chan, Michael C. W. Chan, Nan Jia, Gillian Air, Clark Hopton, Maria P. Wong, Anne Dell, J. S. Malik Peiris, Stuart M. Haslam, John M. Nicholls

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003223

Three-dimensional Structure of Victorivirus HvV190S Suggests Coat Proteins in Most Totiviruses Share a Conserved Core

Sarah E. Dunn, Hua Li, Giovanni Cardone, Max L. Nibert, Said A. Ghabrial, Timothy S. Baker

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003225

Synergistic Induction of Interferon α through TLR-3 and TLR-9 Agonists Identifies CD21 as Interferon α Receptor for the B Cell Response

Dhohyung Kim, Stefan Niewiesk

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003233

Novel Positive Regulatory Role for the SPL6 Transcription Factor in the N TIR-NB-LRR Receptor-Mediated Plant Innate Immunity

Meenu S. Padmanabhan, Shisong Ma, Tessa M. Burch-Smith, Kirk Czymmek, Peter Huijser, Savithramma P. Dinesh-Kumar

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003235

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

Jennifer M. Spangle, Karl Munger

PLOS Pathogens: published March 14, 2013 | https://doi.org/10.1371/journal.ppat.1003237

Nosema ceranae Escapes Fumagillin Control in Honey Bees

Wei-Fone Huang, Leellen F. Solter, Peter M. Yau, Brian S. Imai

PLOS Pathogens: published March 7, 2013 | https://doi.org/10.1371/journal.ppat.1003185

Environmental Predictors of Seasonal Influenza Epidemics across Temperate and Tropical Climates

James D. Tamerius, Jeffrey Shaman, Wladmir J. Alonso, Kimberly Bloom-Feshbach, Christopher K. Uejio, Andrew Comrie, Cécile Viboud

PLOS Pathogens: published March 7, 2013 | https://doi.org/10.1371/journal.ppat.1003194

Glucocortiocoid Treatment of MCMV Infected Newborn Mice Attenuates CNS Inflammation and Limits Deficits in Cerebellar Development

Kate Kosmac, Glenn R. Bantug, Ester P. Pugel, Djurdjica Cekinovic, Stipan Jonjic, William J. Britt

PLOS Pathogens: published March 7, 2013 | https://doi.org/10.1371/journal.ppat.1003200

A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

David Lutje Hulsik, Ying-ying Liu, Nika M. Strokappe, Simone Battella, Mohamed El Khattabi, Laura E. McCoy, Charles Sabin, Andreas Hinz, Miriam Hock, Pauline Macheboeuf, Alexandre M. J. J. Bonvin, Johannes P. M. Langedijk, David Davis, Anna Forsman Quigley, Marlén M. I. Aasa-Chapman, Michael S. Seaman, Alejandra Ramos, Pascal Poignard, Adrien Favier, Jean-Pierre Simorre, Robin A. Weiss, C. Theo Verrips, Winfried Weissenhorn, Lucy Rutten

PLOS Pathogens: published March 7, 2013 | https://doi.org/10.1371/journal.ppat.1003202

Cover

Co-localization of DENV NS5 with UBR4

Opinion

Pearls

Reviews

Research Articles

Related Articles

Related Articles

Related Articles

Related Articles