August 2007

Immunohistochemical analysis of lung tissue from a SARS-CoV-infected cynomolgus macaque stained for SARS-CoV (red) and phosphorylated STAT1 (brown). There is an abundance of phosphorylated STAT1 in the nuclei of alveolar cells, indicating the activation of innate immune responses. However, STAT1 is not activated in most SARS-CoV-infected cells (see de Lang et al, e112).

Image Credit: Photograph by L. Leijten, Erasmus MC.

Review

Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus

Jin Ye

PLOS Pathogens: published August 31, 2007 | https://doi.org/10.1371/journal.ppat.0030108

Research Articles

A Mycobacterium ESX-1–Secreted Virulence Factor with Unique Requirements for Export

Bryant McLaughlin, Janet S Chon, Jason A MacGurn, Fredric Carlsson, Terri L Cheng, Jeffery S Cox, Eric J Brown

PLOS Pathogens: published August 3, 2007 | https://doi.org/10.1371/journal.ppat.0030105

Epigenetic Silencing of Plasmodium falciparum Genes Linked to Erythrocyte Invasion

Alfred Cortés, Celine Carret, Osamu Kaneko, Brian Y. S. Yim Lim, Alasdair Ivens, Anthony A Holder

PLOS Pathogens: published August 3, 2007 | https://doi.org/10.1371/journal.ppat.0030107

Coronavirus Non-Structural Protein 1 Is a Major Pathogenicity Factor: Implications for the Rational Design of Coronavirus Vaccines

Roland Züst, Luisa Cervantes-Barragán, Thomas Kuri, Gjon Blakqori, Friedemann Weber, Burkhard Ludewig, Volker Thiel

PLOS Pathogens: published August 10, 2007 | https://doi.org/10.1371/journal.ppat.0030109

Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages

Toshihiko Suzuki, Luigi Franchi, Claudia Toma, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Naohiro Inohara, Chihiro Sasakawa, Gabriel Nuñez

PLOS Pathogens: published August 10, 2007 | https://doi.org/10.1371/journal.ppat.0030111

Functional Genomics Highlights Differential Induction of Antiviral Pathways in the Lungs of SARS-CoV–Infected Macaques

Anna de Lang, Tracey Baas, Thomas Teal, Lonneke M Leijten, Brandon Rain, Albert D Osterhaus, Bart L Haagmans, Michael G Katze

PLOS Pathogens: published August 10, 2007 | https://doi.org/10.1371/journal.ppat.0030112

Many Globally Isolated AD Hybrid Strains of Cryptococcus neoformans Originated in Africa

Anastasia P Litvintseva, Xiaorong Lin, Irka Templeton, Joseph Heitman, Thomas G Mitchell

PLOS Pathogens: published August 17, 2007 | https://doi.org/10.1371/journal.ppat.0030114

Dual Targeting of Antioxidant and Metabolic Enzymes to the Mitochondrion and the Apicoplast of Toxoplasma gondii

Paco Pino, Bernardo Javier Foth, Lai-Yu Kwok, Lilach Sheiner, Rebecca Schepers, Thierry Soldati, Dominique Soldati-Favre

PLOS Pathogens: published August 31, 2007 | https://doi.org/10.1371/journal.ppat.0030115

V3 Loop Truncations in HIV-1 Envelope Impart Resistance to Coreceptor Inhibitors and Enhanced Sensitivity to Neutralizing Antibodies

Meg M Laakso, Fang-Hua Lee, Beth Haggarty, Caroline Agrawal, Katrina M Nolan, Mark Biscone, Josephine Romano, Andrea P. O Jordan, George J Leslie, Eric G Meissner, Lishan Su, James A Hoxie, Robert W Doms

PLOS Pathogens: published August 24, 2007 | https://doi.org/10.1371/journal.ppat.0030117

Nod1 Signaling Overcomes Resistance of S. pneumoniae to Opsonophagocytic Killing

Elena S Lysenko, Thomas B Clarke, Mikhail Shchepetov, Adam J Ratner, David I Roper, Christopher G Dowson, Jeffrey N Weiser

PLOS Pathogens: published August 24, 2007 | https://doi.org/10.1371/journal.ppat.0030118

Genome Dynamics of Campylobacter jejuni in Response to Bacteriophage Predation

Andrew E Scott, Andrew R Timms, Phillippa L Connerton, Catherine Loc Carrillo, Khairul Adzfa Radzum, Ian F Connerton

PLOS Pathogens: published August 24, 2007 | https://doi.org/10.1371/journal.ppat.0030119

Limits on Replenishment of the Resting CD4⁺ T Cell Reservoir for HIV in Patients on HAART

Ahmad R Sedaghat, Janet D Siliciano, Timothy P Brennan, Claus O Wilke, Robert F Siliciano

PLOS Pathogens: published August 31, 2007 | https://doi.org/10.1371/journal.ppat.0030122

Natural Killer Cells Promote Early CD8 T Cell Responses against Cytomegalovirus

Scott H Robbins, Gilles Bessou, Amélie Cornillon, Nicolas Zucchini, Brigitte Rupp, Zsolt Ruzsics, Torsten Sacher, Elena Tomasello, Eric Vivier, Ulrich H Koszinowski, Marc Dalod

PLOS Pathogens: published August 24, 2007 | https://doi.org/10.1371/journal.ppat.0030123

Role of Dendritic Cells in Differential Susceptibility to Viral Demyelinating Disease

Wanqiu Hou, Eui Young So, Byung S Kim

PLOS Pathogens: published August 24, 2007 | https://doi.org/10.1371/journal.ppat.0030124

In Vitro and In Vivo Neurotoxicity of Prion Protein Oligomers

Steve Simoneau, Human Rezaei, Nicole Salès, Gunnar Kaiser-Schulz, Maxime Lefebvre-Roque, Catherine Vidal, Jean-Guy Fournier, Julien Comte, Franziska Wopfner, Jeanne Grosclaude, Hermann Schätzl, Corinne Ida Lasmézas

PLOS Pathogens: published August 31, 2007 | https://doi.org/10.1371/journal.ppat.0030125

Correction

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

Zabrina L Brumme, Chanson J Brumme, David Heckerman, Bette T Korber, Marcus Daniels, Jonathan Carlson, Carl Kadie, Tanmoy Bhattacharya, Celia Chui, James Szinger, Theresa Mo, Robert S Hogg, Julio S. G Montaner, Nicole Frahm, Christian Brander, Bruce D Walker, P. Richard Harrigan

PLOS Pathogens: published August 31, 2007 | https://doi.org/10.1371/journal.ppat.0030121

Cover

SARS-CoV infection