Figures
Polarized T cells infected with HIV-1 encoding YFP-tagged Gag protein (shown in green).
HIV-1 Gag is the major structural protein that forms virus particles. In a majority of polarized T cells, Gag-YFP concentrates to a rear-end protrusion known as the uropod. As these uropods participate in cell-cell contacts with other cells, Gag accumulation to and virus assembly at uropods may facilitate virus spread. Consistent with this model, uropod components are observed at the virological synapses. Gag localization to uropods are driven by higher-order Gag multimerization dependent on the NC domain (see Llewellyn et al., doi:10.1371/journal.ppat.1001167).
Image Credit: G. Nicholas Llewellyn, University of Michigan Medical School
Citation: (2010) PLoS Pathogens Issue Image | Vol. 6(10) October 2010. PLoS Pathog 6(10): ev06.i10. https://doi.org/10.1371/image.ppat.v06.i10
Published: October 28, 2010
Copyright: © 2010 Llewellyn et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HIV-1 Gag is the major structural protein that forms virus particles. In a majority of polarized T cells, Gag-YFP concentrates to a rear-end protrusion known as the uropod. As these uropods participate in cell-cell contacts with other cells, Gag accumulation to and virus assembly at uropods may facilitate virus spread. Consistent with this model, uropod components are observed at the virological synapses. Gag localization to uropods are driven by higher-order Gag multimerization dependent on the NC domain (see Llewellyn et al., doi:10.1371/journal.ppat.1001167).
Image Credit: G. Nicholas Llewellyn, University of Michigan Medical School