Figures
Invasive EPEC.
Since its discovery in 1945, enteropathogenic Escherichia coli (EPEC) has been considered an extracellular pathogen, which triggers formation of actin-rich pedestal-like structures at the bacterial attachment site. Richard Bulgin et al. discovered a novel category of invasive EPEC. EPEC (blue) invasion via membrane ruffles (red) is dependent on the type III secretion system effector EspT and activation of Rac1 and Wave2. Invasive bacteria reside within an EPEC-containing vacuole (ECV) and trigger formation of intracellular actin pedestals that are essential for intracellular survival/multiplication (see Bulgin et al., doi:10.1371/journal.ppat.1000683).
Image Credit: Richard Bulgin, Centre for Molecular Microbiology and Infection, Imperial College London
Citation: (2009) PLoS Pathogens Issue Image | Vol. 5(12) December 2009. PLoS Pathog 5(12): ev05.i12. https://doi.org/10.1371/image.ppat.v05.i12
Published: December 24, 2009
Copyright: © 2009 Richard Bulgin. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Since its discovery in 1945, enteropathogenic Escherichia coli (EPEC) has been considered an extracellular pathogen, which triggers formation of actin-rich pedestal-like structures at the bacterial attachment site. Richard Bulgin et al. discovered a novel category of invasive EPEC. EPEC (blue) invasion via membrane ruffles (red) is dependent on the type III secretion system effector EspT and activation of Rac1 and Wave2. Invasive bacteria reside within an EPEC-containing vacuole (ECV) and trigger formation of intracellular actin pedestals that are essential for intracellular survival/multiplication (see Bulgin et al., doi:10.1371/journal.ppat.1000683).
Image Credit: Richard Bulgin, Centre for Molecular Microbiology and Infection, Imperial College London