Figures
Chemokines and viral infection of the CNS.
Over the past decade, chemokines have emerged as important components participating in host defense following viral infection by attracting antigen-specific lymphocytes into the CNS to control and eliminate the invading pathogen. However, how chemokines regulate recruitment of myeloid cells to the CNS in response to viral infection has not been well characterized. Hosking et al. provide evidence that ELR-positive chemokines attract neutrophils to the CNS by signaling through the receptor CXCR2. Early expression of CXCL1 (green staining) by glial cells, including astrocytes (red staining), within the microvasculature support early neutrophil recruitment required for optimal host defense (see Hosking et al., doi:10.1371/journal.ppat.1000648).
Image Credit: Martin Hosking, University of California Irvine
Citation: (2009) PLoS Pathogens Issue Image | Vol. 5(11) November 2009. PLoS Pathog 5(11): ev05.i11. https://doi.org/10.1371/image.ppat.v05.i11
Published: November 26, 2009
Copyright: © 2009 Martin Hosking. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Over the past decade, chemokines have emerged as important components participating in host defense following viral infection by attracting antigen-specific lymphocytes into the CNS to control and eliminate the invading pathogen. However, how chemokines regulate recruitment of myeloid cells to the CNS in response to viral infection has not been well characterized. Hosking et al. provide evidence that ELR-positive chemokines attract neutrophils to the CNS by signaling through the receptor CXCR2. Early expression of CXCL1 (green staining) by glial cells, including astrocytes (red staining), within the microvasculature support early neutrophil recruitment required for optimal host defense (see Hosking et al., doi:10.1371/journal.ppat.1000648).
Image Credit: Martin Hosking, University of California Irvine