Figures
Toxoplasma gondii evades IFN-γ-mediated gene expression in murine macrophages.
Parasites interfere with the assembly of chromatin remodeling complexes and histone acetylation at STAT1-regulated promoters. Histone deacetylase inhibitors can rescue Toxoplasma-infected macrophages from unresponsiveness to IFN-γ (see Lang et al., doi:10.1371/journal.ppat.1002483). The inhibition of IFN-γ-induced MHC class II expression (green fluorescence) after infection of macrophages with T. gondii (blue fluorescence) is shown by confocal microscopy; total cells were stained with propidium iodide (red stain).
Image Credit: Carsten Lüder, University Medical Center Göttingen
Citation: (2012) PLoS Pathogens Issue Image | Vol. 8(1) January 2012. PLoS Pathog 8(1): ev08.i01. https://doi.org/10.1371/image.ppat.v08.i01
Published: January 26, 2012
Copyright: © 2012 Lüder. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Parasites interfere with the assembly of chromatin remodeling complexes and histone acetylation at STAT1-regulated promoters. Histone deacetylase inhibitors can rescue Toxoplasma-infected macrophages from unresponsiveness to IFN-γ (see Lang et al., doi:10.1371/journal.ppat.1002483). The inhibition of IFN-γ-induced MHC class II expression (green fluorescence) after infection of macrophages with T. gondii(blue fluorescence) is shown by confocal microscopy; total cells were stained with propidium iodide (red stain).
Image Credit: Carsten Lüder, University Medical Center Göttingen