Figures
Arginase-1-expressing macrophages function as suppressor cells during helminth infection.
Mice deficient in Arginase-1 in macrophages (Arg1-/flox; LysMcre) fail to downregulate the egg-induced inflammatory response when chronically infected with Schistosoma mansoni. The Arg1-/flox; LysMcre also develop severe liver fibrosis, as shown here by second harmonic emission confocal microscopy. The image shows extensive collagen deposition around schistosome eggs lodged in the liver (see Pesce et al., doi:10.1371/journal.ppat.1000371).
Image Credit: Meggan Czapiga, John Pesce, and Tom Wynn, NIAID/NIH.
Citation: (2009) PLoS Pathogens Issue Image | Vol. 5(4) April 2009. PLoS Pathog 5(4): ev05.i04. https://doi.org/10.1371/image.ppat.v05.i04
Published: April 24, 2009
Copyright: © 2009 Czapiga et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mice deficient in Arginase-1 in macrophages (Arg1-/flox; LysMcre) fail to downregulate the egg-induced inflammatory response when chronically infected with Schistosoma mansoni. The Arg1-/flox; LysMcre also develop severe liver fibrosis, as shown here by second harmonic emission confocal microscopy. The image shows extensive collagen deposition around schistosome eggs lodged in the liver (see Pesce et al., doi:10.1371/journal.ppat.1000371).
Image Credit: Meggan Czapiga, John Pesce, and Tom Wynn, NIAID/NIH.