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Open Access
Peer-reviewed
Research Article
Three mutations switch H7N9 influenza to human-type receptor specificity
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Robert P. de Vries ,
Contributed equally to this work with: Robert P. de Vries, Wenjie Peng
Affiliations Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America, Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, CG Utrecht, The Netherlands
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Wenjie Peng ,
Contributed equally to this work with: Robert P. de Vries, Wenjie Peng
Affiliation Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America
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Oliver C. Grant,
Affiliation Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America
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Andrew J. Thompson,
Affiliation Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America
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Xueyong Zhu,
Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America
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Kim M. Bouwman,
Affiliation Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands
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Alba T. Torrents de la Pena,
Affiliation Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
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Marielle J. van Breemen,
Affiliation Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands
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Iresha N. Ambepitiya Wickramasinghe,
Affiliation Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands
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Cornelis A. M. de Haan,
Affiliation Virology Division, Department of Infectious Diseases & Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1,CL Utrecht, The Netherlands
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Wenli Yu,
Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America
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Ryan McBride,
Affiliation Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America
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Rogier W. Sanders,
Affiliations Department of Medical Microbiology, Academic Medical Center, University of Amsterdam, AZ Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weil Medical College of Cornell University, New York, NY, United States of America
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Robert J. Woods,
Affiliation Complex Carbohydrate Research Center, University of Georgia, Athens, GA, United States of America
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Monique H. Verheije,
Affiliation Pathology Division, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, CL Utrecht, The Netherlands
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Ian A. Wilson,
Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, United States of America, Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States of America
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James C. Paulson
* E-mail: jpaulson@scripps.edu
Affiliation Departments of Molecular Medicine, & Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States of America
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Three mutations switch H7N9 influenza to human-type receptor specificity
- Robert P. de Vries,
- Wenjie Peng,
- Oliver C. Grant,
- Andrew J. Thompson,
- Xueyong Zhu,
- Kim M. Bouwman,
- Alba T. Torrents de la Pena,
- Marielle J. van Breemen,
- Iresha N. Ambepitiya Wickramasinghe,
- Cornelis A. M. de Haan
- Published: June 15, 2017
- https://doi.org/10.1371/journal.ppat.1006390