-
Loading metrics
Open Access
Peer-reviewed
Research Article
A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition
-
David Lutje Hulsik ,
Contributed equally to this work with: David Lutje Hulsik, Ying-ying Liu
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ -
Ying-ying Liu ,
Contributed equally to this work with: David Lutje Hulsik, Ying-ying Liu
Current address: Tianjin Medical University, Tianjing, China.
Affiliation Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ -
Nika M. Strokappe,
Affiliation Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ -
Simone Battella,
Affiliation Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ -
Mohamed El Khattabi,
Affiliation Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ -
Laura E. McCoy,
Affiliation MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
⨯ -
Charles Sabin,
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ -
Andreas Hinz,
Current address: Institute of Biochemistry, Goethe-University Frankfurt, Frankfurt/Main, Germany.
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ -
Miriam Hock,
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ -
Pauline Macheboeuf,
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ -
Alexandre M. J. J. Bonvin,
Affiliation Bijvoet Center for Biomolecular Research, Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ -
Johannes P. M. Langedijk,
Current address: Crucell Holland BV, Leiden, The Netherlands.
Affiliation Pepscan Therapeutics BV, Lelystad, The Netherlands
⨯ -
David Davis,
Affiliation Department of Virology, Biomedical Primate Research Centre (BPRC), Rijswijk, The Netherlands
⨯ -
Anna Forsman Quigley,
Affiliation MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
⨯ -
Marlén M. I. Aasa-Chapman,
Affiliation MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
⨯ -
Michael S. Seaman,
Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
⨯ -
Alejandra Ramos,
Affiliation Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America
⨯ -
Pascal Poignard,
Affiliations Department of Immunology and Microbial Science, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative, New York, New York, United States of America
⨯ -
Adrien Favier,
Affiliations CNRS, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France, CEA, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France, UJF-Grenoble-1, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France
⨯ -
Jean-Pierre Simorre,
Affiliations CNRS, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France, CEA, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France, UJF-Grenoble-1, Institut de Biologie Structurale-Jean-Pierre Ebel, Grenoble Cedex, France
⨯ -
Robin A. Weiss,
Affiliation MRC/UCL Centre for Medical Molecular Virology, Division of Infection and Immunity, University College London, London, United Kingdom
⨯ -
C. Theo Verrips,
Affiliations Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands, QVQ BV, Utrecht, The Netherlands
⨯ -
Winfried Weissenhorn ,
* E-mail: weissenhorn@embl.fr (WW); L.Rutten@uu.nl (LR)
Affiliation Unit of Virus Host Cell Interactions (UVHCI), UMI 3265, Université Joseph Fourier-EMBL-CNRS, Grenoble, France
⨯ - [ ... ],
-
Lucy Rutten
* E-mail: weissenhorn@embl.fr (WW); L.Rutten@uu.nl (LR)
Affiliation Biomolecular Imaging (BMI), Faculty of Science, Utrecht University, Utrecht, The Netherlands
⨯ - [ view all ]
- [ view less ]
A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition
- David Lutje Hulsik,
- Ying-ying Liu,
- Nika M. Strokappe,
- Simone Battella,
- Mohamed El Khattabi,
- Laura E. McCoy,
- Charles Sabin,
- Andreas Hinz,
- Miriam Hock,
- Pauline Macheboeuf
- Published: March 7, 2013
- https://doi.org/10.1371/journal.ppat.1003202