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Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

  • Leonie Unterholzner ,

    Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

  • Rebecca P. Sumner ,

    Contributed equally to this work with: Leonie Unterholzner, Rebecca P. Sumner

    Affiliation Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

  • Marcin Baran ,

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

  • Hongwei Ren ,

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    Affiliation Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

  • Daniel S. Mansur,

    Affiliation Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

  • Nollaig M. Bourke,

    Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

  • Felix Randow,

    Affiliation Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom

  • Geoffrey L. Smith ,

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    Affiliation Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, London, United Kingdom

  • Andrew G. Bowie

    agbowie@tcd.ie

    MB and HR also contributed equally to this work. GLS and AGB are joint senior authors on this work.

    Affiliation School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

  • Leonie Unterholzner, 
  • Rebecca P. Sumner, 
  • Marcin Baran, 
  • Hongwei Ren, 
  • Daniel S. Mansur, 
  • Nollaig M. Bourke, 
  • Felix Randow, 
  • Geoffrey L. Smith, 
  • Andrew G. Bowie
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