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Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

  • Elena Gustchina ,

    Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  • Mi Li ,

    Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliations Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America, Basic Research Program, SAIC-Frederick, Frederick, Maryland, United States of America

  • John M. Louis ,

    Contributed equally to this work with: Elena Gustchina, Mi Li, John M. Louis

    Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  • D. Eric Anderson,

    Affiliation Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  • John Lloyd,

    Affiliation Proteomics and Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  • Christian Frisch,

    Affiliation AbD Serotec, MorphoSys AG, Martinsried, Germany

  • Carole A. Bewley,

    Affiliation Laboratory of Biorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  • Alla Gustchina ,

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America

  • Alexander Wlodawer ,

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation Protein Structure Section, Macromolecular Crystallography Laboratory, National Cancer Institute, Frederick, Maryland, United States of America

  • G. Marius Clore

    mariusc@mail.nih.gov (GMC); wlodawer@nih.gov (AW); gustchia@mail.nih.gov (AG)

    Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41

  • Elena Gustchina, 
  • Mi Li, 
  • John M. Louis, 
  • D. Eric Anderson, 
  • John Lloyd, 
  • Christian Frisch, 
  • Carole A. Bewley, 
  • Alla Gustchina, 
  • Alexander Wlodawer, 
  • G. Marius Clore
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