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PGL I expression in live bacteria allows activation of a CD206/PPARγ cross-talk that may contribute to successful Mycobacterium leprae colonization of peripheral nerves

Fig 3

Pre-infection with live BCG PGL I or M. leprae allows BCG WT to enter Schwann cells.

A-B. A higher degree of association and internalization of PKH67-labeled BCG WT (live or irradiated) was observed after pre-infection with live BCG PGL I or M. leprae at MOI 10:1. C. A first stimulus with beads, beads covered with PGL I, and dead M. leprae or dead BCG PLG I did not result in a higher degree of BCG WT internalization. D. Flow cytometric results showed no change in the degree of internalization of PKH67-labeled M. smegmatis after pre-stimulus with M. leprae at MOI 10:1. (NI shows background fluorescence). A-D. Results are represented as mean ± SEM of at least three independent biological replicates; and statistical significance was calculated by ANOVA followed by Bonferroni’s multiple comparison test. *** p<0.001.

Fig 3

doi: https://doi.org/10.1371/journal.ppat.1007151.g003