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GPCR-bigrams: Enigmatic signaling components in oomycetes

Fig 1

Membrane topology of GPCR-bigrams.

GPCR-bigram types with a C-terminal catalytic domain predicted to be intracellular. One type not shown here is AP-GPCR, a GPCR-bigram with an N-terminal aspartic protease domain [10]. Modified from [10]. AC, adenylyl cyclase; DEP, Dishevelled, Egl-10, and Pleckstrin; GPCR, G-protein coupled receptor; INPP, inositol polyphosphate phosphatase; PDE, phosphodiesterase; PIPK, phosphatidylinositol-4-phosphate 5-kinase; PIP, phosphatidylinositol phosphate; TKL, tyrosine kinase-like.

Fig 1

doi: https://doi.org/10.1371/journal.ppat.1007064.g001