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Metabolic reprogramming of Kaposi’s sarcoma associated herpes virus infected B-cells in hypoxia

Fig 6

Common targets of hypoxia and KSHV infection.

A list of genes from BJAB-KSHV, BJAB-CoCl2 and BJAB-KSHV-CoCl2 samples were generated with significant difference when compared to BJAB cells. The lists of gene names were added to the Partek software to identify common up-regulated or common down-regulated genes in these samples compared to BJAB cells. (A) Venn diagram showing common up-regulated factors targeted by hypoxia and KSHV. (B) Venn diagram showing common Down-regulated factors targeted by hypoxia and KSHV. (C) Intensity map for the fold change (RNA sequencing) of DNMT1, DNMT3A and DNMT3B. (D) Real time PCR validation of DNMTs expression. (E) Representative image of Western blot analysis for validation of DNMTs expression. Asterisk (*) indicates differences which are statistically significant (p≤0.05).

Fig 6

doi: https://doi.org/10.1371/journal.ppat.1007062.g006