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Varicella zoster virus productively infects human natural killer cells and manipulates phenotype

Fig 4

CD56dim NK cells are more effective than CD56bright NK cells at supporting VZV infection.

(A) Healthy human donor PBMCs were infected with VZV for 2 days then analysed for infection by flow cytometry. Plots show gating strategy for CD56bright and CD56dim NK cells (CD3CD56+) (left panel), with respective surface VZV gE:gI expression (right panels) from one representative donor (n = >7). (B & C) CD3CD56bright (B) and CD3CD56dim (C) NK cells were isolated from healthy human donor PBMCs by FACS sorting and subsequently infected with VZV for 2 days before analysis by flow cytometry. Plots show surface gE:gI expression from one representative donor (n = 2).

Fig 4

doi: https://doi.org/10.1371/journal.ppat.1006999.g004