Advertisement

< Back to Article

Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

Fig 7

Fab mechanisms of inhibition.

In the absence of Fabs, the Vif E3 ligase is able to ubiquitinate A3 proteins (A3D, F, G, H) and target them for proteasomal degradation. 3C9 inhibits the ubiquitination and degradation of A3F, but not A3G, and rescues A3F packaging. 1D1 prevents the ubiquitination and degradation of A3, and inhibits A3 packaging.

Fig 7

doi: https://doi.org/10.1371/journal.ppat.1006830.g007