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Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors

Fig 1

Fabs bind VCBC with high affinity.

(A) Schematic representation of the Vif E3-ligase with the VCBC components denoted in gray. (B) Overview of Fab panning pipeline. (C) Binding affinities for VCBC-Fab interactions measured by BLI. Consensus Vif was obtained from the Los Alamos National Lab HIV Sequence Database (Alignment ID: 104CP14).

Fig 1

doi: https://doi.org/10.1371/journal.ppat.1006830.g001