Prohibitin plays a critical role in Enterovirus 71 neuropathogenesis
(a) NSC-34 cells were infected with EV71 at M.O.I. 10 and cell lysate was prepared at 6, 24, 48 and 72 h.p.i. for 2DE gel electrophoresis. Representative 2DE image of infected cell lysate at 48 h.p.i. is shown. Three independent experiments were performed. UI, uninfected. (b) Heat map was generated using MultiExperiment Viewer (MeV). Distance was represented by Euclidean average linkage clustering. The host proteins are further categorized into (c) heavily up-regulated and (d) down-regulated proteins.