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HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis

Fig 6

HIF-1α enhances the inhibitory functions of myeloid cells during chronic VL.

Naïve CD4 T cells were stimulated with plate bound αCD3 and αCD28 in the presence of rIL-12. (A) Representative FACS plots showing IFNγ production by CD4 T cells co-incubated or not with CD11b+ cells purified from the spleen of L. donovani infected mice. (B) Percentage of inhibition of IFNγ production calculated as described in the material and methods section. All data represent mean ± SEM of one of 3 independent experiments, n = 3. * denotes p<0.05 and ** denotes p<0.01.

Fig 6