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Reversible unfolding of infectious prion assemblies reveals the existence of an oligomeric elementary brick

Fig 2

Formation of suPrP by different prion strains.

SV profile of suPrP obtained after treatment of the homogenate with 6 M urea without dialysis (red line) and after refolding (blue line) for the 263K (A), T2Ov-19K (B) and T1Ov-21K (C) prion strains. For comparison, the SV sedimentograms for untreated infected brain samples are shown in black.

Fig 2