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A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity

Fig 3

SodM is required to resist CP-imposed Mn starvation.

Wild type, ΔsodA, ΔsodM and ΔsodAΔsodM S. aureus were grown in the presence of increasing concentrations of (A & B) WT CP, (C) the ΔMn/Zn site mutant, or (D) the ΔZn site mutant in the (A) absence and (C-D) presence of 0.1 mM PQ. Growth was assessed by measuring optical density (OD600). * = p<0.05 relative to wild type at the same concentration of CP via two-way ANOVA with Dunnett’s post-test. Error bars indicate SEM (n = 3 or more).

Fig 3

doi: https://doi.org/10.1371/journal.ppat.1006125.g003