A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity
Wild type, ΔsodA, ΔsodM and ΔsodAΔsodM S. aureus were grown in the presence of increasing concentrations of (A & B) WT CP, (C) the ΔMn/Zn site mutant, or (D) the ΔZn site mutant in the (A) absence and (C-D) presence of 0.1 mM PQ. Growth was assessed by measuring optical density (OD600). * = p<0.05 relative to wild type at the same concentration of CP via two-way ANOVA with Dunnett’s post-test. Error bars indicate SEM (n = 3 or more).