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A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity

Fig 1

Expression of sodA and sodM varies by Mn availability.

S. aureus carrying (A, C, & E) pSodA and (B, D, & F) pSodM YFP reporter constructs were grown in the presence of either wild type CP (A-F), the ΔMn/Zn site mutant (C-F), or the ΔZn site mutant (C-F), and in the (A, B, E, & F) presence or (A-D) absence of 0.1 mM PQ. Expression data are normalized to growth. Error bars indicate SEM (n = 3 or more). (A & B) # = p <0.05 via two-way ANOVA with Tukey’s post-test for the indicated comparison. * = p <0.05 via two-way ANOVA with Tukey’s post-test relative to bacteria grown in the presence of paraquat without CP. ^ = p <0.05 via two-way ANOVA with Tukey’s post-test relative to bacteria grown in the absence of both paraquat and CP (C-F) * = p <0.05 via two-way ANOVA with Dunnett’s post-test when compared to wild type CP.

Fig 1

doi: https://doi.org/10.1371/journal.ppat.1006125.g001