Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection
Fig 4
Distribution of PD-1, Lag-3 and Tim-3 expression according to CD8 T cell memory subsets.
Overall distribution of naïve, central memory (TCM), effector memory (TEM) and TEMRA CD8 T cells from pre-therapy baseline samples (a) and percentage expression on each of these subsets at the same time-point of PD-1 (b), Lag-3 (c) and Tim-3 (d). Markers represent medians and interquartile range. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Comparison of exhaustion marker expression across three or more groups was performed using Friedman’s test (non-parametric, paired analysis of variance). Where a difference was found, subsequent pairwise comparisons between groups (Dunn’s test) were performed with adjustment for multiple comparisons targeting on overall significance level of 0.05.